Effects of intranasal oxytocin on thermal pain in healthy men: a randomized functional magnetic resonance imaging study

M Zunhammer, S Geis, V Busch… - Psychosomatic …, 2015 - journals.lww.com
Objective Intranasal oxytocin has been shown to affect human social and emotional
processing, but its potential to affect pain remains elusive. This randomized, placebo …

The effects of intranasal oxytocin in opioid-dependent individuals and healthy control subjects: a pilot study

JD Woolley, PA Arcuni, CS Stauffer, D Fulford… - …, 2016 - Springer
Rationale There has been an explosion of research on the potential benefits of the social
neuropeptide oxytocin for a number of mental disorders including substance use disorders …

Oxytocin and pain: a systematic review and synthesis of findings

JA Rash, A Aguirre-Camacho… - The Clinical journal of …, 2014 - journals.lww.com
Objectives: A review of the literature was conducted to assess the association between
oxytocin (OT) and pain. Methods: PsychInfo, PubMed, and Medline (EBSCO) research …

Where is the love? A double-blind, randomized study of the effects of intranasal oxytocin on stress regulation and aggression

C Romney, J Hahn-Holbrook, GJ Norman… - International journal of …, 2019 - Elsevier
Previous studies reveal that oxytocin (OT) encourages prosocial behavior in humans;
however, animal studies and recent work in humans suggest that OT may also play a role in …

Intranasal oxytocin administration is reflected in human saliva

O Weisman, O Zagoory-Sharon, R Feldman - Psychoneuroendocrinology, 2012 - Elsevier
Following the discovery that intranasal administration of neuropeptides can reach the central
nervous system, a growing number of studies applied intranasal oxytocin (OT) paradigms to …

The correlation between central and peripheral oxytocin concentrations: a systematic review and meta-analysis

M Valstad, GA Alvares, M Egknud… - Neuroscience & …, 2017 - Elsevier
There is growing interest in the role of the oxytocin system in social cognition and behavior.
Peripheral oxytocin concentrations are regularly used to approximate central concentrations …

Elevated salivary levels of oxytocin persist more than 7 h after intranasal administration

MH Van IJzendoorn, R Bhandari… - Frontiers in …, 2012 - frontiersin.org
We addressed the question how long salivary oxytocin levels remain elevated after
intranasal administration, and whether it makes a difference when 16 or 24 IU of oxytocin …

Pain modulation by intranasal oxytocin and emotional picture viewing—a randomized double-blind fMRI study

M Zunhammer, S Geis, V Busch, P Eichhammer… - Scientific reports, 2016 - nature.com
The hormone oxytocin has been hypothesized to influence the emotional dimension of pain.
This randomized, placebo-controlled, double-blind, crossover study explored whether …

Oxytocin and the modulation of pain experience: Implications for chronic pain management

LM Tracy, N Georgiou-Karistianis, SJ Gibson… - Neuroscience & …, 2015 - Elsevier
In an acute environment pain has potential protective benefits. However when pain
becomes chronic this protective effect is lost and the pain becomes an encumbrance …

Phase 1 safety assessment of intrathecal oxytocin

JC Eisenach, C Tong, R Curry - Anesthesiology, 2015 - pubs.asahq.org
Background: Preclinical data suggest that oxytocin reduces hypersensitivity by actions in the
spinal cord, but whether it produces antinociception to acute stimuli is unclear. In this article …