miR-34a deficiency in APP/PS1 mice promotes cognitive function by increasing synaptic plasticity via AMPA and NMDA receptors
Y Xu, P Chen, X Wang, J Yao, S Zhuang - Neuroscience Letters, 2018 - Elsevier
Abstract MicroRNA (miR)-34a was recently determined to contribute to the pathological
development of Alzheimer's disease (AD). miR-34a deficiency significantly attenuates …
development of Alzheimer's disease (AD). miR-34a deficiency significantly attenuates …
miR-34a knockout attenuates cognitive deficits in APP/PS1 mice through inhibition of the amyloidogenic processing of APP
The noncoding miRNA-34a (miR-34a) is involved in Alzheimer's disease (AD)
pathologenesis and shows potential for application as a biomarker for early diagnosis and …
pathologenesis and shows potential for application as a biomarker for early diagnosis and …
miR-30a-5p induces Aβ production via inhibiting the nonamyloidogenic pathway in Alzheimer's disease
T Sun, K Zhao, M Liu, Z Cai, L Zeng, J Zhang… - Pharmacological …, 2022 - Elsevier
Alzheimer's disease (AD) pathogenesis is known to involve a dysregulation of microRNA
expression, and these intricate transcriptional cascades between multiple pathological …
expression, and these intricate transcriptional cascades between multiple pathological …
MicroRNA‐128 suppresses tau phosphorylation and reduces amyloid‐beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's …
Abstract Introduction and Aims Alzheimer's disease (AD) is characterized by the abnormal
accumulation of hyperphosphorylated tau proteins and amyloid‐beta (Aβ) peptides. Recent …
accumulation of hyperphosphorylated tau proteins and amyloid‐beta (Aβ) peptides. Recent …
A novel mechanism of synaptic and cognitive impairments mediated via microRNA-30b in Alzheimer's disease
Background It is widely accepted that cognitive and memory deficits in Alzheimer's disease
(AD) primarily result from synaptic failure. However, the mechanisms that underlie synaptic …
(AD) primarily result from synaptic failure. However, the mechanisms that underlie synaptic …
MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice
W Liu, C Liu, J Zhu, P Shu, B Yin, Y Gong, B Qiang… - Neurobiology of …, 2012 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder mainly characterized
by amyloid-beta (Aβ) deposition and neurofibrillary tangles (NFTs). The abnormal …
by amyloid-beta (Aβ) deposition and neurofibrillary tangles (NFTs). The abnormal …
[HTML][HTML] MicroRNA-338-5p alleviates neuronal apoptosis via directly targeting BCL2L11 in APP/PS1 mice
J Li, D Li, H Zhou, G Wu, Z He, W Liao, Y Li… - Aging (Albany NY …, 2020 - ncbi.nlm.nih.gov
MicroRNAs have become pivotal modulators in the pathogenesis of Alzheimer's disease.
MiR-338-5p is associated with neuronal differentiation and neurogenesis, and expressed …
MiR-338-5p is associated with neuronal differentiation and neurogenesis, and expressed …
miR-23b-3p rescues cognition in Alzheimer's disease by reducing tau phosphorylation and apoptosis via GSK-3β signaling pathways
H Jiang, J Liu, S Guo, L Zeng, Z Cai, J Zhang… - … Therapy-Nucleic Acids, 2022 - cell.com
Dysregulated microRNA (miRNA) expression in the brain can contribute to cognitive
dysfunction and aberrant tau hyperphosphorylation in Alzheimer's disease (AD). Several …
dysfunction and aberrant tau hyperphosphorylation in Alzheimer's disease (AD). Several …
MicroRNA-34c downregulation ameliorates amyloid-β-induced synaptic failure and memory deficits by targeting VAMP2
S Hu, H Wang, K Chen, P Cheng, S Gao… - Journal of …, 2015 - content.iospress.com
MicroRNAs (miRNAs) are small (∼ 22-nucleotide [nt]) noncoding RNAs that regulate
biological processes at the post-transcriptional level. Dysregulation of specific miRNAs …
biological processes at the post-transcriptional level. Dysregulation of specific miRNAs …
Replenishment of microRNA-188-5p restores the synaptic and cognitive deficits in 5XFAD Mouse Model of Alzheimer's Disease
MicroRNAs have emerged as key factors in development, neurogenesis and synaptic
functions in the central nervous system. In the present study, we investigated a …
functions in the central nervous system. In the present study, we investigated a …