Aminoglycosides are recommended for the treatment of Enterococcus faecalis infections,
especially in severe and bacteremic infection. However, the optimal aminoglycoside or the …

Objective: This study tests the usefulness of ceftriaxone combined with ampicillin as an
alternative to ampicillin plus gentamicin for the treatment of experimental endocarditis due to …

We compared the efficacy of ampicillin, both alone and in combination with gentamicin given
once a day (qd) or three times a day (tid), in the treatment of experimental enterococcal …

Several in vitro and in vivo studies as well as clinical trials have demonstrated that once-
daily aminoglycoside regimens are as effective as or more effective than multiple daily …

The penicillin-aminoglycoside combination is recommended for the treatment of systemic
enterococcal infections. However, the optimal dosing regimen of the aminoglycoside …

We compared the pharmacodynamic activities of vancomycin and ampicillin with or without
gentamicin once daily or thrice daily in an in vitro infection model with fibrin–platelet clots …

The purpose of this work was to evaluate the in vitro possibilities of ampicillin-ceftriaxone
combinations for 10 Enterococcus faecalis strains with high-level resistance to …

Once‐daily administration of aminoglycosides (ODA) is effective and safe for many
indications. By optimizing pharmacodynamic principles, it enhances bactericidal activity and …

Aminoglycosides are useful antimicrobial agents for treating infective endocarditis; however,
they occasionally cause troublesome side effects, such as nephrotoxicity and ototoxicity. We …

Today, Enterococcus faecalis is one of the main causes of infective endocarditis in the world,
generally affecting an elderly and fragile population, with a high mortality rate. Enterococci …