Metabolism is a core process underlying essentially all biological functions. The integration
of metabolism with immunity, known as immunometabolism, is at the forefront of immunology …

It is now recognized that obesity is driving the type 2 diabetes epidemic in Western
countries. Obesity-associated chronic tissue inflammation is a key contributing factor to type …

Maintenance of healthy human metabolism depends on a symbiotic consortium among
bacteria, archaea, viruses, fungi, and host eukaryotic cells throughout the human …

Over the past 10 years, the field of immunometabolism made great strides to unveil the
crucial role of intracellular metabolism in regulating immune cell function. Emerging insights …

The immune system defends against pathogens and maintains tissue homeostasis for the
life of the organism. These diverse functions are bioenergetically expensive, requiring …

Low-grade tissue inflammation induced by obesity can result in insulin resistance, which in
turn is a key cause of type 2 diabetes mellitus. Cells of the innate immune system produce …

T cells play pivotal roles in shaping host immune responses in infectious diseases,
autoimmunity, and cancer. The activation of T cells requires immune and growth factor …

Abstract Changes in cellular metabolism are associated with the activation of diverse
immune subsets. These changes are fuelled by nutrients including glucose, amino acids …

The worldwide obesity epidemic has emerged as a major cause of insulin resistance and
Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the …

Immune cells constantly patrol the body via the bloodstream and migrate into multiple
tissues where they face variable and sometimes demanding environmental conditions …