Abstract Selective cyclooxygenase (COX)-2 inhibitors (coxibs) were developed as one of the
anti-inflammatory drugs to avoid the various side effects of non-steroidal anti-inflammatory …

Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to have a
property to inhibit tumor development in some cancers while it shows various side effects …

Although the incidence of gastric cancer has been declining in recent decades, it remains a
major public health issue as the second leading cause of cancer death worldwide. In China …

Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …

Background Various studies suggest that aspirin and other non-steroidal anti-inflammatory
drugs (NSAIDs) are promising anticancer agents. Epidemiological studies have found that …

This chapter briefly summarizes the current knowledge about the role of nonsteroidal anti-
inflammatory drugs (NSAIDs), specially focusing on those selective for cyclooxygenase …

Epidemiological observations and laboratory research have suggested that nonsteroidal
anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of …

The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin
(PG) biosynthesis. Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the …

Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …

COX-2 is overexpressed in gastric intestinal metaplasia, a precancerous condition. COX-2 is
overexpressed in early gastric cancer, in intestinal type but not diffuse type. There may be a …