The biosynthesis of nitric oxide (NO⋅) in different cell types occurs concomitantly with the
conversion ofl-arginine to l-citrulline by the enzyme nitric-oxide synthase (NOS). NO⋅ has …

The mitochondrial production of nitric oxide is catalyzed by a nitric-oxide synthase. This
enzyme has the same cofactor and substrate requirements as other constitutive nitric-oxide …

We reported that the generation of nitric oxide by mitochondria is catalyzed by a constitutive,
mitochondrial nitric-oxide synthase (mtNOS). Given that this production may establish the …

In the present study we show the existence of a functional nitric oxide synthase (NOS) in rat
liver mitochondria. The enzyme uses l-arginine (l-arg) to produce nitric oxide (NO) and l …

The production of nitric oxide (NO) was originally described by Ghafourifar and Richter 1
and by Giulivi et al. 2 in rat liver mitochondria. Later, NO production was reported in brain, 3 …

The effect of O2 concentration on mitochondrial nitric oxide synthase (mtNOS) activity and
on O2− production was determined in rat liver, brain, and kidney submitochondrial …

The biochemistry of the mitochondrial production of nitric oxide is reviewed to gain insight
into the basic role of this radical in mitochondrial and cellular oxidative metabolism. The …

In this article we demonstrate the immunocytochemical localization of nitric oxide synthase
in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal …

Nitric oxide is generated in vivo by nitric-oxide synthase (NOS) during the conversion of L-
Arg to citrulline. Using a variety of biological systems and approaches emerging evidence …

Nitric oxide is a potent modulator of mitochondrial respiration, ATP synthesis, and KATP
channel activity. Recent studies show the presence of a potentionally new isoform of the …