Nitric oxide (NO) is synthesized by members of the NO synthase (NOS) family. Recently the
existence of a mitochondrial NOS (mtNOS), its Ca 2+ dependence, and its relevance for …

Nitric oxide (NO) is an intercellular signaling molecule; among its many and varied roles are
the control of blood flow and blood pressure via activation of the heme enzyme, soluble …

To elucidate the role of nitric oxide (NO) in the regulation of mitochondrial function, the effect
of NO on energy transfer reactions was examined under different oxygen tensions …

Although nitric oxide (. N= O) biosynthesis is inducible in rat hepatocytes (HC), the
physiological significance of. N= O production by these cells is unknown. Short exposure of …

Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at
cytochrome oxidase. Concentrations of NO measured in a range of biological systems are …

Arginase exists in two isoforms. Liver-type arginase (arginase I) is expressed almost
exclusively in the liver and catalyzes the last step of urea synthesis, whereas the nonhepatic …

Mitochondrial nitric oxide synthase (mtNOS), its cellular NOS isoform, and the effects of
mitochondrially produced NO on bioenergetics have been controversial since mtNOS was …

Nitric oxide (NO) can bind to and inhibit the terminal enzyme of the mitochondrial respiratory
chain, cytochrome c oxidase (complex IV). In vivo, NO is made by the NO synthase (NOS) …

Nitric oxide (NO) inhibited the respiration rate of mitochondria isolated from rat heart at sub-
micromolar concentrations of NO. The inhibition was rapidly and completely reversible …

Biological systems that produce or are exposed to nitric oxide (NO⋅) exhibit changes in the
rate of oxygen free radical production. Considering that mitochondria are the main …