Simple Summary Ovarian and endometrial cancers occur frequently and can be lethal.
Recently, progesterone receptor membrane component (PGRMC) 1 and PGRMC2 have …

Various ovarian cell types including granulosa cells and ovarian surface epithelial cells
express the progesterone (P4) binding protein, progesterone receptor membrane …

Progesterone receptor membrane component (PGRMC) proteins play important roles in
tumor growth, progression, and chemoresistance, of which PGRMC1 is the best …

Endometrial cancer is the leading gynecologic cancer in women in the United States with
52,630 women predicted to be diagnosed with the disease in 2014. The objective of this …

Triple negative breast cancers (TNBCs) are highly aggressive and grow in response to sex
steroid hormones despite lacking expression of the classical estrogen (E2) and …

To determine whether progesterone receptor membrane component 1 (PGRMC1) regulates
the development and cisplatin (CDDP)-sensitivity of human ovarian tumors, PGRMC1 was …

Abstract Context: Progesterone (P4) influences ovarian cancer cells by an unknown
mechanism. Objective: The objective was to determine whether P4 acts through …

Hormone signaling is important in a number of disease states, and hormone receptors are
effective therapeutic targets. PGRMC1 (progesterone receptor membrane component 1) is a …

Progesterone receptor membrane component 1 (PGRMC1) is a multi-functional protein with
a heme-binding moiety related to that of cytochrome b 5, which is a putative progesterone …

Progesterone receptor membrane component type 2 (PGRMC2) is strongly homologous to
PGRMC1 which is highly expressed in ovarian cancer and other cancer cells and was …