Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining
both muscle fiber number and size. The myostatin pathway is conserved and regulates …

Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …

Myostatin is a negative regulator of muscle mass. Important advances in our understanding
of the complex biology of this factor have revealed the therapeutic potential of antagonizing …

Genetic deletion of Myostatin, a member of the Transforming Growth Factor-beta family of
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …

Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It
plays a key role in skeletal muscle homeostasis and has now been well described since its …

In the past 20 years, myostatin, a negative regulator of muscle mass, has attracted attention
as a potential therapeutic target in muscular dystrophies and other conditions. Preclinical …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

Since its discovery in 1997, myostatin has quickly been established as a key regulator of
skeletal muscle mass. Recent developments strengthen the idea that myostatin will be an …

Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

Myostatin is an endogenous inhibitor of muscle conserved across diverse species. In the
absence of myostatin, there is massive muscle growth in mice, cattle, and humans. Previous …