Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue
that negatively regulates skeletal muscle mass. Mstn−/− mice have a dramatic increase in …

These studies suggest that proteins and drugs that inactivate myostatin, or interfere with its
binding to its receptor, may be useful for the therapy of wasting and degenerative muscle …

Purpose There is mounting evidence that skeletal muscle produces and secretes
biologically active proteins or “myokines” that facilitate metabolic cross talk between organ …

Myostatin is hypothesized to regulate skeletal muscle mass and to be a potential target for
therapeutic intervention in sarcopenia. To clarify whether myostatin is invariably associated …

Myostatin is a negative regulator of muscle growth. Loss of myostatin has been shown to
cause increase in skeletal muscle size and improve skeletal muscle function and fibrosis in …

Constitutive myostatin gene knockout in mice causes excessive muscle growth during
development. To examine the effect of knocking out the myostatin gene after muscle has …

Myostatin is a member of the transforming growth factor-beta/bone morphogenetic protein
(TGF-β/BMP) super-family of secreted factors that functions as a potent inhibitor of skeletal …

There is much interest in developing anti-myostatin agents to reverse or prevent muscle
atrophy in adults, so it is important to characterize the effects of reducing myostatin activity …

Myostatin, an endogenous negative regulator of skeletal muscle mass, is a therapeutic
target for muscle atrophic disorders. Here, we identified minimum peptides 2 and 7 to …

Background Myostatin (MSTN) is a key negative regulator of muscle mass in humans and
animals, having direct and indirect influences on molecular regulators of atrophy and …