Although it is well established that the lack of myostatin (Mstn) promotes skeletal muscle
hypertrophy, the corresponding changes regarding force generation have been studied …

Abstract Changes in myostatin content and localization in mouse skeletal muscles were
investigated during aging, hindlimb suspension (HS) and reloading after HS. During aging …

Glucocorticoids mediate muscle atrophy in many catabolic states. Myostatin expression, a
negative regulator of muscle growth, is increased by glucocorticoids and myostatin …

Myostatin, a member of the transforming growth factor beta (TGF‐β) superfamily that is
highly expressed in skeletal muscle, was first described in 1997. It has been known that loss …

Skeletal muscle is one of the leading frameworks of the musculo-skeletal system, which
works in synergy with the bones. Long skeletal muscles provide stability and mobility to the …

Myostatin (Mstn) participates in the regulation of skeletal muscle size and has emerged as a
regulator of muscle metabolism. Here, we hypothesized that lack of myostatin profoundly …

Abstract Background Myostatin (Mstn) is a negative regulator of muscle growth whose
inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in …

Myostatin is an extracellular cytokine mostly expressed in skeletal muscles and known to
play a crucial role in the negative regulation of muscle mass. Upon the binding to activin …

Myostatin plays a major role in muscle growth and development and animals with disruption
of this gene display marked increases in muscle mass. Little is known about muscle …

Myostatin (GDF-8) was discovered 25 years ago as a new transforming growth factor-β
family member that acts as a master regulator of skeletal muscle mass. Myostatin is made by …