[HTML][HTML] A binding site model and structure-activity relationships for the rat A3 adenosine receptor
PJM Van Galen, AH VAN BERGEN… - Molecular …, 1994 - ncbi.nlm.nih.gov
SUMMARY A novel adenosine receptor, the A 3 receptor, has recently been cloned. We
have systematically investigated the hitherto largely unexplored structure-activity …
have systematically investigated the hitherto largely unexplored structure-activity …
[HTML][HTML] A threonine residue in the seventh transmembrane domain of the human A1 adenosine receptor mediates specific agonist binding.
A Townsend-Nicholson, PR Schofield - Journal of Biological Chemistry, 1994 - Elsevier
The A1 adenosine receptor is a member of the seven-transmembrane G protein-coupled,
receptor superfamily. This receptor binds the purine nucleoside adenosine with high affinity …
receptor superfamily. This receptor binds the purine nucleoside adenosine with high affinity …
Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions
J Linden - Trends in pharmacological sciences, 1994 - cell.com
In this review, Joel linden summarizes what is known about a new and intriguing member of
the adenosine receptor family, the A3 receptor. This receptor exhibits unusually large …
the adenosine receptor family, the A3 receptor. This receptor exhibits unusually large …
[HTML][HTML] Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors.
ME Olah, KA Jacobson, GL Stiles - Journal of Biological Chemistry, 1994 - Elsevier
Adenosine receptor (AR) agonists and antagonists are approximately 100-fold and 100,000-
fold, respectively, more potent at the bovine A1AR as compared to the rat A3AR. To …
fold, respectively, more potent at the bovine A1AR as compared to the rat A3AR. To …
A carboxyl-terminally truncated mutant and nonglycosylated A2a adenosine receptors retain ligand binding.
CE Piersen, CD True, JN Wells - Molecular pharmacology, 1994 - ASPET
The amino acids that comprise the ligand binding sites of adenosine receptors have not
been identified. Adenosine and its agonist analogues differ from ligands for the well studied …
been identified. Adenosine and its agonist analogues differ from ligands for the well studied …
Cloning and expression of the A2a adenosine receptor from guinea pig brain
F Meng, G Xie, D Chalmers, C Morgan… - Neurochemical …, 1994 - Springer
A full-length complementary DNA (cDNA) clone encoding the guinea pig brain A 2
adenosine receptor has been isolated by polymerase chain reaction (PCR) and low …
adenosine receptor has been isolated by polymerase chain reaction (PCR) and low …
Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]‐SCH 58261
S Dionisotti, E Ongini, C Zocchi, B Kull… - British journal of …, 1997 - Wiley Online Library
We have characterized the binding of the new potent and selective antagonist radioligand
[3H]‐5‐amino‐7‐(2‐phenylethyl)‐2‐(2‐furyl)‐pyrazolo [4, 3‐e]‐1, 2, 4‐triazolo [1, 5‐c] …
[3H]‐5‐amino‐7‐(2‐phenylethyl)‐2‐(2‐furyl)‐pyrazolo [4, 3‐e]‐1, 2, 4‐triazolo [1, 5‐c] …
Serine and alanine mutagenesis of the nine native cysteine residues of the human A1 adenosine receptor
DJ Scholl, JN Wells - Biochemical pharmacology, 2000 - Elsevier
To examine the importance of the nine native cysteine residues in the human A1 adenosine
receptor, each cysteine was individually mutated to both serine and alanine. Saturation …
receptor, each cysteine was individually mutated to both serine and alanine. Saturation …
N6-Bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor
BK Trivedi, AJ Bridges, WC Patt… - Journal of medicinal …, 1989 - ACS Publications
Sir: Adenosine elicits a wide variety of physiological re-sponses1 via interactions with two
major subtypes of ex-tracellular adenosine receptors, designated as Ax and A2. and A2 …
major subtypes of ex-tracellular adenosine receptors, designated as Ax and A2. and A2 …
[HTML][HTML] 125I-4-aminobenzyl-5′-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor
ME Olah, C Gallo-Rodriguez, KA Jacobson… - Molecular …, 1994 - ncbi.nlm.nih.gov
The rat A 3 adenosine receptor (AR) is a recently characterized AR subtype cloned from
testis and brain cDNA libraries. N 6-2-(4-Amino-3-[125 I] iodophenyl) ethyladenosine, a high …
testis and brain cDNA libraries. N 6-2-(4-Amino-3-[125 I] iodophenyl) ethyladenosine, a high …