We investigated the cross-neutralising potential of serum and nasal wash samples from
volunteers who were intranasally immunised once with a monovalent replication-deficient …

The nonstructural protein 1 (NS1) of influenza A virus (IAV) enables the virus to disarm the
host cell type 1 IFN defense system. Mutation or deletion of the NS1 gene leads to …

Despite the availability of vaccines that efficiently reduce the severity of clinical symptoms,
influenza viruses still cause substantial morbidity and mortality worldwide. In this regard …

The levels and properties of neutralizing antibodies in nasal wash and serum collected from
five healthy adults were examined after intranasal administration of an A/Uruguay/716/2007 …

Haemagglutination inhibition (HI) and neutralization (NT) titers as well as haemagglutinin
(HA) specific antibody responses were examined in 50 healthy adults aged between 22 and …

The effect of the current influenza vaccine, an inactivated virus vaccine administered by
subcutaneous/intramuscular injection, is limited to reducing the morbidity and mortality …

Background The non-structural protein NS1 of the influenza virus counteracts the interferon-
mediated immune response of the host. We investigated the safety and immunogenicity of a …

Intranasally administered influenza vaccines could be more effective than injected vaccines,
because intranasal vaccination can induce virus‐specific immunoglobulin A (IgA) antibodies …

Influenza viruses cause annual epidemics and occasional pandemics. The high diversity of
viral envelope proteins permits viruses to escape host immunity. Therefore, the development …

Introduction: Intranasal influenza vaccines are expected to confer protection among vaccine
recipients by successful induction of mucosal immune response in the upper respiratory …