HLA-DM catalyzes peptide dissociation and exchange in class II MHC molecules through a
mechanism that has been proposed to involve the disruption of specific components of the …

The class II MHC homolog HLA-DM catalyzes exchange of peptides bound to class II MHC
proteins, and is an important component of the Ag presentation machinery. The mechanism …

HLA-DM catalyzes peptide loading and exchange reactions by MHC class II molecules.
Soluble recombinant DM, lacking transmembrane and cytoplasmic domains, was observed …

The mechanism by which HLA-DM (DM) promotes exchange of peptides bound to HLA-DR
(DR) is still unclear. We have shown that peptide interaction with DR1 can be considered a …

The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major
histocompatibility (MHC) class II molecules during antigen processing; however, the …

The binding of peptides to MHC class II molecules is mediated in part by a conserved array
of intermolecular hydrogen bonds. We have evaluated the consequences of disrupting the …

Introduction 3. MHC class II synthesis and assembly with chaperones 4. Biochemical and
structural characterization of DM 5. The molecular mechanism of DM function 5.1 …

Abstract HLA-DM (DM) is a heterodimeric MHC molecule that catalyzes the peptide loading
of classical MHC class II molecules in the endosomal/lysosomal compartments of APCs …

The peptide editor HLA-DM (DM) catalyzes the exchange of peptides bound to MHC class II
molecules within antigen presenting cells by generating a “peptide-receptive” MHC class II …

Human histocompatibility leukocyte antigen (HLA)-DM is a major histocompatibility complex
(MHC)-like protein that catalyzes exchange of antigenic peptides from MHC class II …