One hundred thirty-four patients with a variety of malignancies were treated in two phase I
clinical trials of recombinant leukocyte A interferon (IFL-rA) produced by recombinant DNA …

Interferon, induced in lymphocytes either with viruses or cell lines, increases severalfold the
natural cytotoxicity of human lymphocytes on target cell lines. Cell separation experiments …

MATERIALS AND METHODS Culture conditions. All target cells were cultured, and
experiments were carried out at 37 C in a humidified air atmosphere with 5% Con. using …

The in vitro cytotoxic activity of peripheral blood lymphocytes from patients with primary
biliary cirrhosis was investigated to determine the mechanism of deficient spontaneous cell …

Injection of mice with several interferon inducers, Newcastle Disease virus, polyinosinic-
polycytidylic acid and tilorone resulted in an increase in spleen cell cytotoxicity for 51 …

Effector cells in carcinomatous pleural effusions of patients with primary or secondary lung
cancer were examined for natural killer (NK) activity against K562 cells in a 4-h chromium …

Natural killer (NK) cells have been implicated in defense against malignancies, especially
leukemia. Because patients with leukemia and preleukemic disorders manifest low NK …

Natural killer (NK) cells have been studied in human neoplastic diseases in an effort to
assess the role of these cells in the control of human neoplasia and to monitor the effects of …

Natural killer (NK) cells and NK cell activity were determined in three groups (newly
diagnosed [n= 21], on therapy [n= 21], and off therapy [n= 18]) of children with various types …

Lymphocytes prepared from the blood, tumour‐draining lymph node and tumour were tested
for immune reactivity with freshly isolated autologous tumour cells from biopsies. Reactivity …