Effect of chemotherapeutic agents on natural cell-mediated cytotoxicity in mice

A Mantovani, W Luini, G Peri, A Vecchi… - Journal of the …, 1978 - academic.oup.com
Spleen natural killer (NK) activity was Investigated In cells from C57BL/6J mice treated with
various chemotherapeutic agents; 51Cr-labeled YAC-1 lymphoma cells were used as …

Natural killer cell activity associated with reticulum cell neoplasms

KSS Chang, T Log - International Journal of Cancer, 1980 - Wiley Online Library
A marked increase in natural killer (NK) activity is observed with lymphoid cells prepared
from SJL/J mouse spleen and lymph nodes, in which a transplantable reticulum‐cell …

In Vitro Generation and Antitumor Activity of Adherent Lymphokine-activated Killer Cells from the Blood of Patients with Brain Tumors

TL Whiteside, YL Wang, RG Selker, RB Herberman - Cancer research, 1988 - AACR
A procedure for enrichment in recombinant interleukin-2 (rIL2)-activated natural killer (NK)
cells was developed and used for in vitro generation of antitumor effector cells from the …

Lysis of fresh leukemic blasts by interferon-activated human natural killer cells.

PK Pattengale, C Sundstrom, AL Yu… - Natural immunity and …, 1983 - europepmc.org
In a comprehensive study of 30 leukemia patients, it was found that a measurable fraction of
fresh leukemic blasts from 8 of 8 adult patients with chronic myelogenous leukemia (CML) in …

Regulation of natural killer activity in vivo. II. The effect of alcohol consumption on human peripheral blood natural killer activity

QB Saxena, E Mezey, WH Adler - International Journal of …, 1980 - Wiley Online Library
Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32
alcoholics and 15 control subjects in a 4‐h chromium release assay using K562 tumor target …

Suppression of natural killer cell activity by surgical stress in cancer patients and the underlying mechanisms.

H Yoshihara, N Tanaka, K Orita - Acta Medica Okayama, 1986 - europepmc.org
The influence of surgical stress on the natural killer (NK) activity of peripheral blood
lymphocytes in patients with carcinoma of the lung or gastrointestinal system was studied …

Natural killer cells are responsible for the interferon production induced in human lymphocytes by tumor cell contact

T Timonen, E Saksela, I Virtanen… - European Journal of …, 1980 - Wiley Online Library
The identity of cells producing interferon among human peripheral blood lymphocytes in
contact with tumor cells was investigated. The producer cells were target cell‐adherent …

Low doses of interferon alpha result in more effective clinical natural killer cell activation.

BS Edwards, JA Merritt, RC Fuhlbrigge… - The Journal of …, 1985 - Am Soc Clin Investig
To define critical parameters concerning interferon (IFN) effects upon natural killer (NK) cells
in vivo, we gave cancer patients serial weekly intramuscular injections of purified …

Studies on natural killer (NK) cells. III. The effects of in vitro culture on spontaneous cytotoxicity of murine spleen cells.

SP Bartlett, RC Burton - Journal of immunology (Baltimore, Md …, 1982 - journals.aai.org
In vitro culture of normal lymphohemopoietic cells is a complex event leading to the
generation of a diverse group of effector cells. When murine spleen cells are cultured by …

Augmentation of cell‐mediated cytotoxicity to a rat lymphoma. III. In vitro stimulation of natural killer cells by a soluble factor

GR Shellam, V Winterbourn… - International Journal of …, 1980 - Wiley Online Library
The in vitro cytotoxicity of rat natural killer cells was augmented by the incubation of normal
spleen cells with a soluble factor derived from the 24‐h culture of spleen cells and various …