[HTML][HTML] The Outcome of CLL Patients According to IGHV Mutational Status: An Israeli Perspective

Y Bronstein, S Levi, S Tsuriel, YS Arbel, E Joffe… - Blood, 2021 - Elsevier
Introduction: The prognostic significance of immunoglobulin heavy-chain variable region
gene (IGHV) mutational status in chronic lymphocytic leukemia (CLL) is well established …

Prevalence of Clonal Hematopoiesis of Indeterminate Potential in Patients with Monoclonal B-Cell Lymphocytosis Compared to Untreated Chronic Lymphocytic …

AV Patel, A Vijenthira, A Sekar, CJ Gibson… - Blood, 2022 - ashpublications.org
Background: Monoclonal B-cell lymphocytosis (MBL) is a benign precursor condition to
chronic lymphocytic leukemia (CLL). Clonal hematopoiesis of indeterminate potential (CHIP) …

Incidence of chronic lymphocytic leukemia and high‐count monoclonal B‐cell lymphocytosis using the 2008 guidelines

TG Call, AD Norman, CA Hanson, SJ Achenbach… - Cancer, 2014 - Wiley Online Library
BACKGROUND The 1996 National Cancer Institute Working Group (NCI‐WG 96) guidelines
classified disease in individuals who had a B‐cell clone with chronic lymphocytic leukemia …

Redefining the prognostic likelihood of chronic lymphocytic leukaemia patients with borderline percentage of immunoglobulin variable heavy chain region mutations

S Raponi, C Ilari, I Della Starza… - British Journal of …, 2020 - Wiley Online Library
In chronic lymphocytic leukaemia (CLL), caution is warranted regarding the clinical
implications of immunoglobulin variable heavy chain region (IGHV) rearrangements with a …

Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification

P Strati, TD Shanafelt - Blood, The Journal of the American …, 2015 - ashpublications.org
Monoclonal B lymphocytosis (MBL) is defined as the presence of a clonal B-cell population
in the peripheral blood with fewer than 5× 109/L B-cells and no other signs of a …

Clinical Presentation, Progression, and Outcome of Patients With Clonal B-Cell Counts of Less Than 5 × 109/L, 5 to 10 × 109/L, and More Than 10 × 109/L and …

AE Foster, TDT Nguyen, N Al-Hammadi… - American journal of …, 2015 - academic.oup.com
Objectives: The flow cytometric evaluation of peripheral lymphocytosis has led to a dramatic
increase in the diagnosis of early stage chronic lymphocytic leukemia (CLL) and monoclonal …

Clinical progression and outcome of patients with monoclonal B-cell lymphocytosis

SS Fung, KL Hillier, CS Leger, I Sandhu… - Leukemia & …, 2007 - Taylor & Francis
Monoclonal B-cell lymphocytosis (MBL) is a clonal lymphoproliferation with the
immunophenotype of chronic lymphocytic leukemia (CLL) but a B-lymphocyte count of less …

Why is the immunoglobulin heavy chain gene mutation status a prognostic indicator in chronic lymphocytic leukemia?

U Rozovski, MJ Keating, Z Estrov - Acta haematologica, 2018 - karger.com
The immunoglobulin heavy chain gene (IgHV) mutation status correlates with the clinical
outcome of patients with chronic lymphocytic leukemia (CLL) treated with …

Different prognostic impact of recurrent gene mutations in IGHV-mutated and IGHV-unmutated chronic lymphocytic leukemia: a retrospective, multi-center cohort study …

L Mansouri, B Thorvaldsdottir, LA Sutton… - Blood, 2021 - ashpublications.org
The mutational status of the immunoglobuin heavy variable (IGHV) genes is an undisputable
strong prognostic factor that subdivides patients with chronic lymphocytic leukemia (CLL) …

[HTML][HTML] Combined patterns of IGHV repertoire and cytogenetic/molecular alterations in monoclonal B lymphocytosis versus chronic lymphocytic leukemia

A Henriques, A Rodríguez-Caballero, WG Nieto… - PloS one, 2013 - journals.plos.org
Background Chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis (MBL)
with (MBLhi) or without (MBLlo) absolute B-lymphocytosis precedes most CLL cases, the …