Atrial fibrillation (AF) associated with fibrosis is characterized by the appearance of
interstitial myofibroblasts. These cells are responsible for the uncontrolled deposition of the …

associated with increased fibroblast densities. However, in these preparations, longitudinal
conduction velocity was increased rather than reduced, whereas myofibroblasts were not …

Atrial fibrillation (AF) is regularly accompanied by cardiac fibrosis and concomitant heart
failure. Due to the heterogeneous nature and complexity of fibrosis, the knowledge about the …

Myocardial injury, mechanical stress, neurohormonal activation, inflammation, and/or aging
all lead to cardiac remodeling, which is responsible for cardiac dysfunction and …

Cardiac pathologies leading to the development of organ fibrosis typically are associated
with the appearance of interstitial myofibroblasts. This cell type plays a central role in …

In the healthy heart, cardiac myocytes form an electrical syncytium embedded in a
supportive fibroblast-rich extracellular matrix designed to optimize the electromechanical …

During atrial fibrillation, cardiac tissue undergoes different remodeling processes at different
scales from the molecular level to the tissue level. One central player that contributes to both …

Atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia in clinical
practice. However, current therapeutic interventions for atrial fibrillation have limited clinical …

Introduction: The genesis of atrial fibrillation (AF) and success of AF ablation therapy have
been strongly linked with atrial fibrosis. Increasing evidence suggests that patient-specific …

Objective Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling,
contributing to the progressive nature of the arrhythmia. Ventricular dysfunction due to a …