Gold nanoparticle toxicity in mice and rats: species differences

J Bahamonde, B Brenseke, MY Chan… - Toxicologic …, 2018 - journals.sagepub.com
Nanotoxicity studies are greatly needed to advance nanomedical technologies into clinical
practice. We assessed the toxic effects of a single intravenous exposure to commercially …

Assessment of the in vivo toxicity of gold nanoparticles

YS Chen, YC Hung, I Liau, GS Huang - Nanoscale research letters, 2009 - Springer
The environmental impact of nanoparticles is evident; however, their toxicity due to their
nanosize is rarely discussed. Gold nanoparticles (GNPs) may serve as a promising model to …

Size-dependent in vivo toxicity of PEG-coated gold nanoparticles

XD Zhang, D Wu, X Shen, PX Liu, N Yang… - International journal …, 2011 - Taylor & Francis
Background Gold nanoparticle toxicity research is currently leading towards the in vivo
experiment. Most toxicology data show that the surface chemistry and physical dimensions …

Uptake of gold nanoparticles in murine macrophage cells without cytotoxicity or production of pro-inflammatory mediators

Q Zhang, VM Hitchins, AM Schrand, SM Hussain… - …, 2011 - Taylor & Francis
More information characterizing the biological responses to nanoparticles is needed to allow
the US Food and Drug Administration to evaluate the safety and effectiveness of products …

Systematic in vitro toxicological screening of gold nanoparticles designed for nanomedicine applications

PC Naha, P Chhour, DP Cormode - Toxicology in Vitro, 2015 - Elsevier
Gold nanoparticles (AuNP) are increasingly being applied in the biomedical field as
therapeutics, contrast agents, and in diagnostic systems, motivating investigations of their …

Histopathology of the liver, kidney, and spleen of mice exposed to gold nanoparticles

KE Ibrahim, MG Al-Mutary, AO Bakhiet, HA Khan - Molecules, 2018 - mdpi.com
Gold nanoparticles (GNPs) are biocompatible nanomaterials that are currently researched
for biomedical applications such as imaging and targeted drug delivery. In this investigation …

Toxicologic effects of gold nanoparticles in vivo by different administration routes

XD Zhang, HY Wu, D Wu, YY Wang… - International journal …, 2010 - Taylor & Francis
Gold nanoparticles have potential applications in biomedicine, but one of the important
concerns is about their safety. Most toxicology data are derived from in vitro studies and may …

Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice

C Lasagna-Reeves, D Gonzalez-Romero… - Biochemical and …, 2010 - Elsevier
Gold nanoparticles (GNPs) offer a great promise in biomedicine. Currently, there is no data
available regarding the accumulation of nanoparticles in vivo after repeated administration …

Differential cytotoxic effects of gold nanoparticles in different mammalian cell lines

PJ Chueh, RY Liang, YH Lee, ZM Zeng… - Journal of hazardous …, 2014 - Elsevier
Gold nanoparticles (AuNPs) possess unique properties that have been exploited in several
medical applications. However, a more comprehensive understanding of the environmental …

Biodistribution and acute toxicity of naked gold nanoparticles in a rabbit hepatic tumor model

ES Glazer, C Zhu, AN Hamir, A Borne… - …, 2011 - Taylor & Francis
There is a paucity of data regarding the safety of administering solid gold nanoparticles
(AuNPs) in large animal tumor models. We assessed the acute toxicity and biodistribution of …