The mouse is the most widely used animal model for influenza virus research. However, the
susceptibility of mice to seasonal influenza virus depends on the strain of mouse and on the …

Elucidating the genetic basis of influenza A viruses (IAVs) is important to understand which
mutations will determine the virulence and the host range of mammals. Here, seasonal …

In 2009, a swine-origin H1N1 influenza virus caused the first pandemic of the 21st century.
To understand the molecular basis of pandemic influenza virus adaptation to new host …

The experimental infection of a mouse lung with influenza A virus has proven to be an
invaluable model for studying the mechanisms of viral adaptation and virulence. The mouse …

ABSTRACT H6N6 viruses are commonly isolated from domestic ducks, and avian-to-swine
transmissions of H6N6 viruses have been detected in China. Whether subsequent …

The molecular mechanism by which pandemic 2009 influenza A viruses were able to
sufficiently adapt to humans is largely unknown. Subsequent human infections with novel …

Influenza impressively reflects the paradigm of a viral disease in which continued evolution
of the virus is of paramount importance for annual epidemics and occasional pandemics in …

Highly pathogenic H5N1 influenza A viruses continue to circulate among avian species and
cause sporadic cases of human infection. Therefore, the threat of a pandemic persists …

Influenza A virus can infect a wide variety of animal species with illness ranging from mild to
severe, and is a continual cause for concern. Genetic mutations that occur either naturally or …

Highly pathogenic H5N1 influenza A virus remains a substantial threat to public health. To
understand the molecular basis and host mechanism for the high virulence of H5N1 viruses …