Heart formation requires the fusion of bilateral cardiomyocyte populations as they move
toward the embryonic midline. The bHLH transcription factor Hand2 is essential for cardiac …

Heart formation requires the fusion of bilateral cardiomyocyte populations as they move
towards the embryonic midline. The bHLH transcription factor Hand2 is essential for cardiac …

Embryonic heart formation requires the production of an appropriate number of
cardiomyocytes; likewise, cardiac regeneration following injury relies upon the recovery of …

Rationale: The basic helix–loop–helix (bHLH) transcription factors Hand1 and Hand2 are
essential for embryonic development. Given their requirement for cardiogenesis, it is …

The precise origins of myocardial progenitors and their subsequent contribution to the
developing heart has been an area of considerable activity within the field of cardiovascular …

Coordinated cardiomyocyte growth, differentiation, and morphogenesis are essential for
heart formation. We demonstrate that the bHLH transcription factors Hand1 and Hand2 play …

Cardiogenesis involves the contributions of multiple progenitor pools, including mesoderm-
derived cardiac progenitors known as the first and second heart fields. Disruption of genetic …

Myocardial differentiation is initiated by the activation of terminal-differentiation gene
expression within a subset of cells in the anterior lateral plate mesoderm. We have …

The bHLH transcription factor, Hand1 has been implicated in cardiac looping in the mouse,
however its function in the developing heart remains unknown. To investigate the …

Basic helix–loop–helix (bHLH) transcription factors control developmental decisions for a
wide range of embryonic cell types. Hand1 and Hand2 are closely related bHLH proteins …