There is no accepted definition of what constitutes onset of antidepressant effect, and this
limits evaluation of the validity of many comparative reports. In order to clarify the nature of …

Remission of depressive symptoms is the goal of all antidepressant therapy. Rating scales
define remission in clinical trials, but it is unclear how well these definitions predict risk of …

Abstract Background Patients with Major Depressive Disorder (MDD) who are non-
improvers after two weeks of antidepressant treatment have a high risk of treatment failure …

Objective: Current clinical knowledge holds that antidepressants have a delayed onset of
efficacy. However, the delayed onset hypothesis has been questioned recently by survival …

Background Few studies have investigated the proportion of patients with depression who
experience worsening of depression symptoms during adequate antidepressant treatment …

This study was aimed at resolving the time course of clinical action of antidepressants (ADs)
and the type of early behavioral changes that precede recovery in treatment-responsive …

Although antidepressant medications are effective in about 50-70% of patients with major
depressive disorder (MDD), they have a delayed onset of therapeutic effect. This latency is …

Abstract Background In Major Depressive Disorder (MDD), the traditional belief of a delayed
onset of antidepressants' effects has lead to the concept of current guidelines that treatment …

Ob jec tiv es: This study inve sti ga ted hypothesized early symptom ch an ges as diff erential
predictors of long-term remission for duloxetine and escita lop ra m. E xp eri men tal Design …

Antidepressants must be taken for weeks before response can be assessed with many
patients not responding to the first medication prescribed. This often results in long delays …