Importance Antidepressants are commonly used to treat major depressive disorder (MDD).
Antidepressant outcomes can vary based on individual differences; however, it is unclear …

Individual variability in treatment response to antidepressants in major depression:
comparing trial-level and patient-level analyses In treatment trials, as well as in clinical …

The outcome of antidepressant drug treatment was measured in 200 patients, 145 seen in
psychiatric out-patient clinics and 55 in general practice, after 4 weeks of therapy. The …

Background: A subset of patients experience worsening of depressed mood after beginning
antidepressant treatment, which could represent the natural history of the illness or a …

Objective To estimate the 12‐week remission rate of patients with depressive disorders and
predictors of this in a naturalistic clinical setting in South Korea. Methods For people with …

Objective: This observational study examined the effectiveness of somatic antidepressant
treatments as administered in the community. Method: The study group consisted of 285 …

Background: Most natural history studies of affective disorders have emphasized the
prediction of eventual recovery. Little is known of changes over time in the immediate …

Objectives Clinical variables were investigated in the 'treatment resistant depression (TRD)‐
III'sample to replicate earlier findings by the European research consortium 'Group for the …

Background: The possibility that antidepressant drugs, while effectively treating depression,
may worsen its course has received inadequate attention. Method: A review of the literature …

The goal of treatment of major depression should be full remission. Many patients, however,
fail to achieve or maintain symptom-free status. Residual depressive symptoms are …