Quantitative analysis of dynamic Gd‐DTPA enhancement in breast tumors using a permeability model

PS Tofts, B Berkowitz… - Magnetic resonance in …, 1995 - Wiley Online Library
The MRI signal enhancement in a breast tumor, measured as a function of time after a bolus
injection of Gd‐DTPA, may contain enough information to differentiate malignant from …

Measurement of vascular volume fraction and blood‐tissue permeability constants with a pharmacokinetic model: studies in rat muscle tumors with dynamic Gd‐DTPA …

MY Su, JC Jao, O Nalcioglu - Magnetic resonance in medicine, 1994 - Wiley Online Library
We propose a compartmental model to explain the signal enhancement curves following the
bolus injection of Gd‐DTPA. The model incorporates vascular volume fraction contribution …

Dynamic contrast‐enhanced MRI using Gd‐DTPA: interindividual variability of the arterial input function and consequences for the assessment of kinetics in tumors

RE Port, MV Knopp, G Brix - … in Medicine: An Official Journal of …, 2001 - Wiley Online Library
Gd‐DTPA kinetics in arterial blood was investigated by dynamic MRI in 47 patients with
malignant and benign mammary tumors. Signal enhancement was monitored for 10 min …

Measurement of the blood‐brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts

PS Tofts, AG Kermode - Magnetic resonance in medicine, 1991 - Wiley Online Library
Leakage of Gd‐DTPA through a defective blood‐brain barrier is measured quantitatively
using dynamic MRI scanning, in which repeated scans are made after a bolus injection …

Simultaneous MRI measurement of blood flow, blood volume, and capillary permeability in mammary tumors using two different contrast agents

E Henderson, J Sykes, D Drost… - Journal of Magnetic …, 2000 - Wiley Online Library
A technique for the simultaneous measurement of three vascular parameters: blood flow
(Fρ), blood volume (vb), and the capillary permeability‐surface area product (PSρ) in breast …

Probing tumor microvascularity by measurement, analysis and display of contrast agent uptake kinetics

GJM Parker, J Suckling, SF Tanner… - Journal of Magnetic …, 1997 - Wiley Online Library
This paper describes a measurement protocol for acquiring quantitative dynamic MRI data
and novel analysis and display software (Magnetic Resonance Imaging Workbench …

Dynamic MR imaging of the breast combined with analysis of contrast agent kinetics in the differentiation of primary breast tumours

S Mussurakis, DL Buckley, PJ Drew, JN Fox… - Clinical radiology, 1997 - Elsevier
Objective: To assess dynamic Gd-DTPA-enhanced magnetic resonance (MR) imaging in the
diagnosis of primary breast pathology, and to test the hypothesis that analysis of contrast …

Method for quantitative mapping of dynamic MRI contrast agent uptake in human tumors

M Rijpkema, JHAM Kaanders… - Journal of Magnetic …, 2001 - Wiley Online Library
A method is presented for the acquisition and analysis of dynamic contrast‐enhanced (DCE)
MRI data, focused on the characterization of tumors in humans. Gadolinium (Gd) contrast …

Functional magnetic resonance of human breast tumors: diffusion and perfusion imaging

S Sinha, U Sinha - Annals of the New York Academy of …, 2002 - Wiley Online Library
This review is focused on two relatively new developments in magnetic resonance imaging
(MRI) and their application to breast lesion characterization: diffusion and perfusion MRI …

Dynamic echo-planar imaging of the breast: experience in diagnosing breast carcinoma and correlation with tumor angiogenesis.

CA Hulka, WB Edmister, BL Smith, L Tan, DC Sgroi… - Radiology, 1997 - pubs.rsna.org
PURPOSE: To correlate quantitative echo-planar magnetic resonance (MR) imaging
measures of gadopentetate dimeglumine tumor uptake with histologic diagnoses and …