Apelin and its receptor APJ in cardiovascular diseases

XH Yu, ZB Tang, LJ Liu, H Qian, SL Tang, DW Zhang… - Clinica Chimica …, 2014 - Elsevier
Apelin is an adipokine that has been identified as an endogenous ligand for the orphan
receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular …

[HTML][HTML] The role of apelin in cardiovascular diseases, obesity and cancer

MB Wysocka, K Pietraszek-Gremplewicz… - Frontiers in …, 2018 - frontiersin.org
Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …

The therapeutic potentials of apelin in obesity-associated diseases

I Castan-Laurell, C Dray, P Valet - Molecular and Cellular Endocrinology, 2021 - Elsevier
Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its
receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has …

[HTML][HTML] Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases

JC Zhong, ZZ Zhang, W Wang, SMK McKinnie… - … et Biophysica Acta (BBA …, 2017 - Elsevier
The apelin/apelin receptor system is widely distributed and has a dominant role in
cardiovascular homeostasis and disease. The apelin gene is X-linked and is synthesized as …

[PDF][PDF] Apelin and ACE2 in cardiovascular disease

AZ Kalea, D Batlle - Curr Opin Investig Drugs, 2010 - researchgate.net
Apelin is a peptide that has been identified as the endogenous ligand for the receptor APJ.
The apelin/APJ system may be an important factor in the regulation of vascular tone and …

Vascular effects of apelin: Mechanisms and therapeutic potential

A Mughal, ST O'Rourke - Pharmacology & therapeutics, 2018 - Elsevier
Apelin is a vasoactive peptide and is an endogenous ligand for APJ receptors, which are
widely expressed in blood vessels, heart, and cardiovascular regulatory regions of the brain …

Translational promise of the apelin–APJ system

G Barnes, AG Japp, DE Newby - Heart, 2010 - heart.bmj.com
Apelin, the endogenous ligand for the G-protein-coupled APJ receptor, is emerging as a key
hormone in cardiovascular homoeostasis. It is expressed in a diverse range of tissues with …

Apelin and APJ, a novel critical factor and therapeutic target for atherosclerosis

D Lv, H Li, L Chen - Acta Biochim Biophys Sin, 2013 - academic.oup.com
Apelin is a bioactive peptide discovered recently that has been proved to be an endogenous
ligand of the APJ receptor. Apelin and APJ are widely distributed in the central nervous …

The apelinergic system: a promising therapeutic target

I Falcão-Pires, R Ladeiras-Lopes… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: Apelin is a bioactive peptide known as the ligand of the G-protein-
coupled receptor APJ. In recent years, there has been a growing body of evidence regarding …

[HTML][HTML] Expanding role for the apelin/APJ system in physiopathology

C Carpéné, C Dray, C Attané, P Valet… - Journal of physiology …, 2007 - ncbi.nlm.nih.gov
Apelin is a bioactive peptide known as the ligand of the G protein-coupled receptor APJ.
Diverse active apelin peptides exist under the form of 13, 17 or 36 amino acids, originated …