The apelinergic system is widely expressed and acts through autocrine and paracrine
signaling to exert protective effects, including vasodilatory, metabolic, and inotropic effects …

The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological
roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are …

Apelin is a novel peptide that acts through the APJ receptor, sharing similarities with the
angiotensin II–angiotensin II type 1 receptor pathway. It is a peripheral vasodilator, powerful …

Apelin is a recently described endogenous peptide and its receptor APJ, is a member of the
G protein-coupled receptors family. Apelin and APJ are widely distributed in central and …

Abstract Apelin and Elabela (Ela) are peptides encoded by APLN and APELA, respectively,
which act on their receptor APJ and play crucial roles in the body. Recent research has …

Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several
active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated …

The apelin receptor (APJ; gene symbol APLNR) is a member of the G protein-coupled
receptor gene family. Neural gene expression patterns of APJ, and its cognate ligand apelin …

Apelin is a recently discovered peptide, identified as an endogenous ligand of receptor APJ.
Apelin and receptor APJ are expressed in a wide variety of tissues including heart, brain …

Background and purpose: The aim of this study was to determine whether the apelin/APJ
system is altered in human cardiovascular disease by investigating whether the expression …

Apelin peptides and the apelin receptor represent a relatively new therapeutic axis for the
potential treatment of cardiovascular disease. Several reports suggest apelin receptor …