Apelin receptors, present on vascular smooth muscle cells, endothelium, and
cardiomyocytes, are activated by the family of apelin peptides to elicit cardiovascular effects …

Apelin acts as the endogenous ligand of G protein coupled receptors APJ. The apelin/APJ
system is responsible for the occurrence and development of cardiovascular diseases. In …

Apelin is an endogenous peptide acting on the APJ receptor. It consists of several isoforms
characterized by different numbers of amino acids. The number of amino acids in the active …

The APJ is a class A, rhodopsin-like G protein-coupled receptor (GPCR) with high sequence
similarity to the angiotensin receptor AT1. APJ has been shown to be widely expressed in …

Apelin is a peptide recently isolated from bovine stomach extracts which appears to act as
an endogenous ligand for the previously orphaned G-protein-coupled APJ receptor. The …

Background Apelin is a peptide ligand for a class A G-protein coupled receptor called the
apelin receptor (AR or APJ) that regulates angiogenesis, the adipoinsular axis, and …

APJ is a G protein‐coupled receptor and its endogenous ligand is apelin. Studies have
shown that apelin/APJ system is widely distributed in the body, especially highly expressed …

Background Apelin is an endogenous ligand for the G protein-coupled receptor APJ. The
association between apelin and cardiac modeling has been reported. However, if serum …

Apelin is a peptide known to have a vital role in cardiovascular diseases. It has been proven
to induce proliferation and tube formation in endothelial cells, stabilise contacts between …

Apelin and its cognate G protein–coupled receptor APJ constitute a signaling pathway with a
positive inotropic effect on cardiac function and a vasodepressor function in the systemic …