The recently identified endogenous peptide apelin and its specific apelin receptor (APJ) are
currently being considered as potential regulators in vascular tissue. Previously, we reported …

This paper focuses on the contribution of apelin in obesity associated regulations/
dysregulations. The conclusions are summarized as follows:(i) apelin is produced by fat …

Type 2 diabetes mellitus (T2DM) is an epidemic with an ever-increasing global prevalence.
Current treatment strategies, although plentiful and somewhat effective, often fail to achieve …

Apelin and its G-protein-coupled receptor APJ are potent regulators of the cardiovascular
system. Recent studies have suggested that apelin–APJ reverses the function of angiotensin …

Apelin increases coronary blood flow, cardiac contractility, and cardiac output. Based on
these favorable hemodynamic effects, apelin and apelin-like analogs are being developed …

Apelin and Elabela (ELA) are endogenous ligands of angiotensin domain type 1 receptor-
associated proteins (APJ). Apelin/ELA-APJ signal is widely distributed in the cardiovascular …

The Apelin/APJ system is involved in a wide range of biological functions. For a long time,
Apelin was thought to be the only ligand for APJ. Recently, a new peptide that acts via APJ …

Background: Apelin, the novel endogenous ligand for the G‐protein‐coupled receptor APJ,
has shown positive inotropic, vasodilatory and diuretic properties in animal studies …

The apelin and Elabela proteins constitute a spatiotemporal double-ligand system that
controls apelin receptor (APJ) signal transduction. Phosphorylation of multiple sites within …

Apelin-13 in blood pressure regulation and cardiovascular di... : Current Opinion in Nephrology
and Hypertension Apelin-13 in blood pressure regulation and cardiovascular disease : Current …