Signaling by the peptide ligand apelin and its cognate G protein-coupled receptor APJ has a
potent inotropic effect on cardiac contractility and modulates systemic vascular resistance …

Apelin is an adipokine secreted by adipocytes. Co-expression of apelin and apelin receptor
(APJ) in adipocytes implies the autocrine regulations of apelin on adipocyte functions …

The novel 36-amino acid peptide, apelin, is the endogenous ligand for the orphan receptor
APJ. Apelin may play important roles in the regulation of the cardiovascular system and the …

Objective: The apelin receptor APJ is a putative receptor protein related to angiotensin (Ang)
type 1 receptor. The apelin-APJ system has been implicated in diabetes, but its role in the …

Objective Apelin–a novel multifunction peptide implicated in regulation of the cardiovascular
system, including blood pressure and cardiac function control–has been postulated to be …

The apelin ligand receptor system is an important target to develop treatment strategies for
cardiovascular diseases. Although apelin exhibits strong inotropic effects, its pharmaceutical …

Apelin is the endogenous ligand of the G protein-coupled receptor APJ. Both Apelin and
APJ receptor are widely distributed in various tissues such as heart, brain, limbs, retina and …

Studies have shown significant cardiovascular effects of exogenous apelin administration,
including the potent activation of cardiac contraction. However, the role of the endogenous …

The novel G protein-coupled receptor APJ, recently paired with the proposed cognate
peptide ligand apelin, mediates potent vasodilator and positive inotropic actions in rats …

Apelin is the endogenous ligand of APJ, which belongs to the family of G protein‑coupled
receptors. Apelin and APJ are highly expressed in various cardiovascular tissues, including …