Apelin is an endogenous peptide that is a ligand for the APJ receptor (angiotensin II receptor
like-1, AT-1). The apelin/APJ system is distributed in diverse periphery organ tissues. It has …

APJ, an orphan G protein‐coupled receptor, is first identified through homology cloning in
1993. Apelin is endogenous ligand of APJ extracted from bovine stomach tissue in 1998 …

The G protein-coupled apelin receptor regulates important processes of the cardiovascular
homeostasis, including cardiac development, cardiac contractility, and vascular tone. Most …

Apelin plays a prominent role in body fluid and cardiovascular homeostasis. To explore
further upstream the role played by this peptide, nonpeptidic agonists and antagonists of the …

BACKGROUND: Apelin is a novel endogenous peptide with inotropic and vasodilatory
properties that is the ligand for the APJ receptor. Apelin and APJ are widely distributed in the …

Angiotensin‐converting enzyme 2 (ACE2)/Ang II/Ang 1–7 and the apelin/APJ are two
important peptide systems which exert diverse effects on the cardiovascular system. ACE2 is …

Background—Apelin, the endogenous ligand for the novel G protein–coupled receptor APJ,
has major cardiovascular effects in preclinical models. The study objectives were to …