Abstract Objective: Osteopontin (OPN), a pleiotropic extracellular matrix glycoprotein, has
been reported to be protective against ischemic lesions, but effects of OPN on vascular …

Cerebral vasospasm (CVS) is an important pathological process following subarachnoid
hemorrhage (SAH). Osteopontin (OPN), a pleiotropic extracellular glycoprotein, has been …

Background and Purpose—Recombinant osteopontin (rOPN) has been reported to be
neuroprotective in stroke animal models. The purpose of this study is to investigate a …

Background and Purpose—Osteopontin (OPN) is an inducible, multifunctional, extracellular
matrix protein that may be protective against blood-brain barrier (BBB) disruption after …

Aims Osteopontin (OPN) has demonstrated neuroprotective effects in various stroke models.
Its role in neuroinflammation after brain injury remains to be elucidated. This study aims to …

Focal brain ischemia induces inflammation, extracellular matrix remodeling, gliosis, and
neovascularization. Osteopontin (OPN) is a secreted glycoprotein that has been implicated …

Osteopontin (OPN) is a secreted extracellular phosphoprotein involved in diverse biologic
functions, including inflammation, cell migration, and antiapoptotic processes. Here we …

Background Osteopontin (OPN), an extracellular matrix glycoprotein, has been reported to
inhibit inducible nitric oxide synthase (iNOS). We examined if recombinant OPN (r-OPN) …

Osteopontin (OPN) is a phosphorylated glycoprotein possessing an arginine-glycine-
aspartate (RGD)-motif, which binds to several cell surface integrins and mediates a wide …

Osteopontin (OPN) is an adhesive glycoprotein linked to a variety of pathophysiological
processes, with neuroprotective properties in ischemic injury. We examined the …