Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage
Abstract Objective: Osteopontin (OPN), a pleiotropic extracellular matrix glycoprotein, has
been reported to be protective against ischemic lesions, but effects of OPN on vascular …
been reported to be protective against ischemic lesions, but effects of OPN on vascular …
Recombinant osteopontin attenuates experimental cerebral vasospasm following subarachnoid hemorrhage in rats through an anti-apoptotic mechanism
J He, M Liu, Z Liu, L Luo - Brain research, 2015 - Elsevier
Cerebral vasospasm (CVS) is an important pathological process following subarachnoid
hemorrhage (SAH). Osteopontin (OPN), a pleiotropic extracellular glycoprotein, has been …
hemorrhage (SAH). Osteopontin (OPN), a pleiotropic extracellular glycoprotein, has been …
Recombinant osteopontin stabilizes smooth muscle cell phenotype via integrin receptor/integrin-linked kinase/Rac-1 pathway after subarachnoid hemorrhage in rats
J Wu, Y Zhang, P Yang, B Enkhjargal, A Manaenko… - Stroke, 2016 - Am Heart Assoc
Background and Purpose—Recombinant osteopontin (rOPN) has been reported to be
neuroprotective in stroke animal models. The purpose of this study is to investigate a …
neuroprotective in stroke animal models. The purpose of this study is to investigate a …
Mechanisms of osteopontin-induced stabilization of blood-brain barrier disruption after subarachnoid hemorrhage in rats
Background and Purpose—Osteopontin (OPN) is an inducible, multifunctional, extracellular
matrix protein that may be protective against blood-brain barrier (BBB) disruption after …
matrix protein that may be protective against blood-brain barrier (BBB) disruption after …
Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats
C Sun, MSU Rahman, B Enkhjargal, J Peng… - Experimental …, 2024 - Elsevier
Aims Osteopontin (OPN) has demonstrated neuroprotective effects in various stroke models.
Its role in neuroinflammation after brain injury remains to be elucidated. This study aims to …
Its role in neuroinflammation after brain injury remains to be elucidated. This study aims to …
Delayed expression of osteopontin after focal stroke in the rat
X Wang, C Louden, TL Yue, JA Ellison… - Journal of …, 1998 - Soc Neuroscience
Focal brain ischemia induces inflammation, extracellular matrix remodeling, gliosis, and
neovascularization. Osteopontin (OPN) is a secreted glycoprotein that has been implicated …
neovascularization. Osteopontin (OPN) is a secreted glycoprotein that has been implicated …
Neuroprotection by osteopontin in stroke
R Meller, SL Stevens, M Minami… - Journal of Cerebral …, 2005 - journals.sagepub.com
Osteopontin (OPN) is a secreted extracellular phosphoprotein involved in diverse biologic
functions, including inflammation, cell migration, and antiapoptotic processes. Here we …
functions, including inflammation, cell migration, and antiapoptotic processes. Here we …
Recombinant osteopontin attenuates brain injury after intracerebral hemorrhage in mice
B Wu, Q Ma, H Suzuki, C Chen, W Liu, J Tang… - Neurocritical care, 2011 - Springer
Background Osteopontin (OPN), an extracellular matrix glycoprotein, has been reported to
inhibit inducible nitric oxide synthase (iNOS). We examined if recombinant OPN (r-OPN) …
inhibit inducible nitric oxide synthase (iNOS). We examined if recombinant OPN (r-OPN) …
Intranasal Delivery of RGD Motif-Containing Osteopontin Icosamer Confers Neuroprotection in the Postischemic Brain via αvβ3 Integrin Binding
YC Jin, H Lee, SW Kim, ID Kim, HK Lee, Y Lee… - Molecular …, 2016 - Springer
Osteopontin (OPN) is a phosphorylated glycoprotein possessing an arginine-glycine-
aspartate (RGD)-motif, which binds to several cell surface integrins and mediates a wide …
aspartate (RGD)-motif, which binds to several cell surface integrins and mediates a wide …
Transient microglial and prolonged astroglial upregulation of osteopontin following transient forebrain ischemia in rats
JS Choi, HY Kim, JH Cha, JY Choi, MY Lee - Brain research, 2007 - Elsevier
Osteopontin (OPN) is an adhesive glycoprotein linked to a variety of pathophysiological
processes, with neuroprotective properties in ischemic injury. We examined the …
processes, with neuroprotective properties in ischemic injury. We examined the …
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