[HTML][HTML] Pannexin1: insight into inflammatory conditions and its potential involvement in multiple organ dysfunction syndrome
X Chen, S Yuan, L Mi, Y Long, H He - Frontiers in Immunology, 2023 - frontiersin.org
Sepsis represents a global health concern, and patients with severe sepsis are at risk of
experiencing MODS (multiple organ dysfunction syndrome), which is associated with …
experiencing MODS (multiple organ dysfunction syndrome), which is associated with …
Pannexins in acute kidney injury
N Poudel, MD Okusa - Nephron, 2019 - karger.com
Acute kidney injury (AKI) is highly prevalent among hospitalized patients and is associated
with serious consequences with limited pharmacological treatment options. Pannexin 1 …
with serious consequences with limited pharmacological treatment options. Pannexin 1 …
[HTML][HTML] Enhanced macrophage pannexin 1 expression and hemichannel activation exacerbates lethal experimental sepsis
W Chen, S Zhu, Y Wang, J Li, X Qiang, X Zhao… - Scientific Reports, 2019 - nature.com
We have recently reported an important role of Connexin 43 (Cx43) hemichannels in the
pathogenesis of lethal sepsis through facilitating ATP efflux to potentiate the double …
pathogenesis of lethal sepsis through facilitating ATP efflux to potentiate the double …
[HTML][HTML] Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury
Abstract Pannexin 1 (Panx1) is a ubiquitously expressed protein forming large conductance
channels that are central to many distinct inflammation and injury responses. There is …
channels that are central to many distinct inflammation and injury responses. There is …
[HTML][HTML] Pannexin1 channels—a potential therapeutic target in inflammation
OM Rusiecka, M Tournier, F Molica… - Frontiers in Cell and …, 2022 - frontiersin.org
An exaggerated inflammatory response is the hallmark of a plethora of disorders. ATP is a
central signaling molecule that orchestrates the initiation and resolution of the inflammatory …
central signaling molecule that orchestrates the initiation and resolution of the inflammatory …
Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis
G Huang, J Bao, X Shao, W Zhou, B Wu, Z Ni, L Wang - Life sciences, 2020 - Elsevier
Aims Sepsis-induced acute kidney injury (SI-AKI) is the fifth most common cause of hospital-
acquired acute kidney injury. Pannexin1 (Panx1) triggers inflammation and apoptosis which …
acquired acute kidney injury. Pannexin1 (Panx1) triggers inflammation and apoptosis which …
[HTML][HTML] The role of pannexin1 in the induction and resolution of inflammation
SE Adamson, N Leitinger - FEBS letters, 2014 - Elsevier
Extracellular ATP is an important signaling molecule throughout the inflammatory cascade,
serving as a danger signal that causes activation of the inflammasome, enhancement of …
serving as a danger signal that causes activation of the inflammasome, enhancement of …
Pannexin 1 channels control cardiomyocyte metabolism and neutrophil recruitment during non-ischemic heart failure
CM Pavelec, AP Young, HL Luviano, EE Orrell… - bioRxiv, 2023 - biorxiv.org
Abstract Pannexin 1 (PANX1), a ubiquitously expressed ATP release membrane channel,
has been shown to play a role in inflammation, blood pressure regulation, and myocardial …
has been shown to play a role in inflammation, blood pressure regulation, and myocardial …
Pannexin-1 influences peritoneal cavity cell population but is not involved in NLRP3 inflammasome activation
Abstract Pannexin-1 (Panx1) forms nonselective large channel in cell plasma membrane
and has been shown to be associated with NLRP3 inflammasome activation, ATP release …
and has been shown to be associated with NLRP3 inflammasome activation, ATP release …
The pannexin-1 channel inhibitor probenecid attenuates skeletal muscle cellular energy crisis and histopathological injury in a rabbit endotoxemia model
H He, D Liu, Y Long, X Wang, B Yao - Inflammation, 2018 - Springer
This study aimed to investigate the effect of probenecid (Pro) as an inhibitor of the pannexin-
1 (Panx-1) channel-mediated release of intracellular ATP to the extracellular compartment …
1 (Panx-1) channel-mediated release of intracellular ATP to the extracellular compartment …