Sepsis represents a global health concern, and patients with severe sepsis are at risk of
experiencing MODS (multiple organ dysfunction syndrome), which is associated with …

Acute kidney injury (AKI) is highly prevalent among hospitalized patients and is associated
with serious consequences with limited pharmacological treatment options. Pannexin 1 …

We have recently reported an important role of Connexin 43 (Cx43) hemichannels in the
pathogenesis of lethal sepsis through facilitating ATP efflux to potentiate the double …

Abstract Pannexin 1 (Panx1) is a ubiquitously expressed protein forming large conductance
channels that are central to many distinct inflammation and injury responses. There is …

An exaggerated inflammatory response is the hallmark of a plethora of disorders. ATP is a
central signaling molecule that orchestrates the initiation and resolution of the inflammatory …

Aims Sepsis-induced acute kidney injury (SI-AKI) is the fifth most common cause of hospital-
acquired acute kidney injury. Pannexin1 (Panx1) triggers inflammation and apoptosis which …

Extracellular ATP is an important signaling molecule throughout the inflammatory cascade,
serving as a danger signal that causes activation of the inflammasome, enhancement of …

Abstract Pannexin 1 (PANX1), a ubiquitously expressed ATP release membrane channel,
has been shown to play a role in inflammation, blood pressure regulation, and myocardial …

Abstract Pannexin-1 (Panx1) forms nonselective large channel in cell plasma membrane
and has been shown to be associated with NLRP3 inflammasome activation, ATP release …

This study aimed to investigate the effect of probenecid (Pro) as an inhibitor of the pannexin-
1 (Panx-1) channel-mediated release of intracellular ATP to the extracellular compartment …