Endothelial dysfunction/activation underlies the development of long-term cardiovascular
complications and atherosclerosis. The aim of this study was to examine a direct role for …

The endothelial generation of reactive oxygen species (ROS) is important both
physiologically and in the pathogenesis of many cardiovascular disorders. ROS generated …

We have recently shown that superoxide and hydrogen peroxide are putative inducers of
angiogenesis in vivo, possibly through up regulation of inducible nitric oxide synthase (NOS) …

Role of Superoxide as a Signaling Molecule | Physiology PHYSIOLOGY.ORG Skip main
navigation Close Drawer MenuOpen Drawer Menu Home Journals AJP-Cell AJP-Endo AJP-GI …

The role of reactive oxygen species (ROS) in the pathogenesis of vascular diseases is well
established, but few data exist on the mechanisms by which ROS induce endothelial cell …

Oxidative stress occurs when the production of reactive oxygen species (ROS) exceeds the
capacity of the cell to detoxify these potentially injurious oxidants using endogenous …

Ischaemia/reperfusion of cardiac tissue has been claimed to be associated with the
production of oxygen free radicals, which can contribute to severe membrane damage and …

Pro-inflammatory activation of vascular endothelium is implicated in pathogenesis of severe
conditions including stroke, infarction and sepsis. We have recently reported that superoxide …

In intact vessels, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) act as
an integrated system, possibly through reactive oxygen species (ROS). Using a coculture …

Aims Vascular disease states are associated with endothelial dysfunction and increased
production of reactive oxygen species derived from NADPH oxidases. However, it remains …