Intracellular targets for antidiabetic sulfonylureas and potassium channel openers
A Szewczyk - Biochemical pharmacology, 1997 - Elsevier
Antidiabetic sulfonylureas and potassium channel openers affect the activity of the ATP-
regulated potassium channel (KATP channel) present in the plasma membrane of various …
regulated potassium channel (KATP channel) present in the plasma membrane of various …
Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides
H de Wet, P Proks - Biochemical Society Transactions, 2015 - portlandpress.com
Sulphonylureas stimulate insulin secretion from pancreatic β-cells primarily by closing ATP-
sensitive K+ channels in the β-cell plasma membrane. The mechanism of channel inhibition …
sensitive K+ channels in the β-cell plasma membrane. The mechanism of channel inhibition …
ATP-sensitive K+ channels and insulin secretion: their role in health and disease
FM Ashcroft, FM Gribble - Diabetologia, 1999 - search.proquest.com
Sulphonylureas have been used for over 50 years to enhance insulin secretion in patients
with Type II (non-insulin-dependent) diabetes mellitus but their therapeutic target was not …
with Type II (non-insulin-dependent) diabetes mellitus but their therapeutic target was not …
Tissue-specific effects of sulfonylureas: lessons from studies of cloned KATP channels
FM Ashcroft, FM Gribble - Journal of Diabetes and its Complications, 2000 - Elsevier
Sulfonylureas stimulate insulin secretion in type-2 diabetic patients by blocking ATP-
sensitive (KATP) potassium channels in the pancreatic β-cell membrane. This effect is …
sensitive (KATP) potassium channels in the pancreatic β-cell membrane. This effect is …
Sulphonylurea action revisited: the post-cloning era
FM Gribble, F Reimann - Diabetologia, 2003 - Springer
Hypoglycaemic agents such as sulphonylureas and the newer group of" glinides" stimulate
insulin secretion by closing ATP-sensitive potassium (K ATP) channels in pancreatic beta …
insulin secretion by closing ATP-sensitive potassium (K ATP) channels in pancreatic beta …
Intracellular location of KATP channels and sulphonylurea receptors in the pancreatic β-cell: new targets for oral antidiabetic agents
Diabetes Mellitus is by far one of the most propagated chronic diseases, affecting 150
million people worldwide. This affliction is caused by a malfunction of pancreatic endocrine …
million people worldwide. This affliction is caused by a malfunction of pancreatic endocrine …
Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells
CL Lawrence, P Proks, GC Rodrigo, P Jones… - Diabetologia, 2001 - Springer
Aims/hypothesis: Sulphonylureas stimulate insulin secretion by closing ATP-sensitive
potassium (K ATP) channels in the pancreatic beta-cell membrane. K ATP channels are also …
potassium (K ATP) channels in the pancreatic beta-cell membrane. K ATP channels are also …
Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels fromcells and extrapancreatic tissues
FM Gribble, FM Ashcroft - Metabolism, 2000 - Elsevier
Sulfonylureas are widely used to stimulate insulin secretion in type 2 diabetic patients
because they close adenosine triphosphate-sensitive potassium (KATP) channels in the …
because they close adenosine triphosphate-sensitive potassium (KATP) channels in the …
Inhibition of ATP-sensitive K+-channels by a sulfonylurea analogue with a phosphate group
K Hastedt, U Panten - Biochemical pharmacology, 2003 - Elsevier
Hypoglycaemic sulfonylureas initiate insulin secretion by direct inhibition of ATP-sensitive
K+-channels in the pancreatic β-cells. These channels are composed of two proteins, a pore …
K+-channels in the pancreatic β-cells. These channels are composed of two proteins, a pore …
Intracellular ATP-sensitive K+ channels in mouse pancreatic beta cells: against a role in organelle cation homeostasis
A Varadi, A Grant, M McCormack, T Nicolson… - Diabetologia, 2006 - Springer
Aims/hypothesis ATP-sensitive K+(K ATP) channels located on the beta cell plasma
membrane play a critical role in regulating insulin secretion and are targets for the …
membrane play a critical role in regulating insulin secretion and are targets for the …
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