Previous data showed the development of tolerance to a variety of pharmacological effects
of plant and synthetic cannabinoids when administered chronically. This tolerance …

The time course of changes across 21 days of continuous exposure to Δ9-
tetrahydrocannabinol (Δ9-THC) was assessed for the level of cannabinoid receptor (CB1) …

Recent studies have demonstrated that the pharmacological tolerance observed after
prolonged exposure to plant or synthetic cannabinoids in adult individuals seems to have a …

The effects of chronic Δ9-tetrahydrocannabinol on cannabinoid receptor levels and receptor–
G-protein coupling were investigated. Male Sprague–Dawley rats were infused continuously …

Specific cannabinoid receptors have been recently described in extrapyramidal and limbic
areas and presumably might mediate the effects of marijuana exposure on behavioral …

The inhibition of motor behavior in rodents caused by the exposure to plant or synthetic
cannabinoids has been reported to develop tolerance after repeated exposure. This …

USING in situ hybridization we found that chronic treatment with CP-55,940 (0.4 mg kg− 1, ip
daily for 11 days), a synthetic cannabinoid receptor ligand, changed cannabinoid receptor …

The active ingredient of marijuana is (−)-Δ 9-tetrahydrocannabinol (Δ 9-THC). Δ 9-THC and
other natural and synthetic cannabinoids such as CP-55, 940 inhibit spontaneous activity …

The CB1‐type cannabinoid receptor mediates physiologic effects of Δ9‐
tetrahydrocannabinol, the psychoactive ingredient of the drug marijuana. In this report, the …

A brain constituent, the N-amide derivative of arachidonic acid, termed anandamide, has
been recently proposed as a possible endogenous ligand for the cannabinoid receptor. The …