In the last decade, immunotherapy with monoclonal antibodies targeting immunological
check points has become a breakthrough therapeutic modality for solid cancers. However …

Gene-targeted mice have recently revealed a role for lymphocytes and interferon-γ (IFNγ) in
conferring protection against cancer, but the mechanisms remain unclear. Here, we have …

Tumor escape from the immune system hampers effective immunotherapy for cancer.
Recent evidence indicates that in cancer patients the altered activities of 2 innatelike …

Summary CD4 and CD8 T cells play a pivotal role in controlling tumor growth. However, the
interplay of both cell types and their role in tumor suppression still remain elusive. In this …

There has been growing interest in the role of B cells in antitumour immunity and potential
use in adoptive cellular therapies. To date, the success of such therapies is limited. The …

While showing promise, vaccination strategies to treat cancer require further optimization.
Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral …

With the regulatory approval of Provenge and Talimogene laherparepvec (T-VEC) for the
treatment of metastatic prostate cancer and advanced melanoma respectively, and other …

When naïve T cells reconstitute lymphopenic hosts, they transiently proliferate and
differentiate into memory-like T cells. Here we report that tumor-specific T cells preferentially …

Although the importance of CD4+ T-cell help for generation of an effective CD8+ effector
cytotoxic T cell (CTL) response is well established, the role of T-cell help in the activation of …

Background DC are potent APC that can activate both CD4 and CD8 T cells in vitro and in
vivo. Although the efficacy of DC-based cancer vaccines is currently being evaluated in …