Targeted modulation of immune cells and tissues using engineered biomaterials

P Yousefpour, K Ni, DJ Irvine - Nature reviews bioengineering, 2023 - nature.com
Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …

Advancing immunotherapy using biomaterials to control tissue, cellular, and molecular level immune signaling in skin

SA Shah, RS Oakes, CM Jewell - Advanced Drug Delivery Reviews, 2024 - Elsevier
Immunotherapies have been transformative in many areas, including cancer treatments,
allergies, and autoimmune diseases. However, significant challenges persist in extending …

Delivery Route Considerations for Designing Antigen‐Specific Biomaterial Strategies to Combat Autoimmunity

MA Ackun-Farmmer, CM Jewell - Advanced NanoBiomed …, 2023 - Wiley Online Library
Disease‐modifying drugs and biologics used to treat autoimmune diseases, although
promising, are non‐curative. As the field moves toward development of new approaches to …

Macroscale biomaterials strategies for local immunomodulation

MO Dellacherie, BR Seo, DJ Mooney - Nature Reviews Materials, 2019 - nature.com
The immune system plays key roles in tissue homeostatic and disease processes, and
manipulation of innate and adaptive immune responses is of great promise for a wide array …

Unlocking Transplant Tolerance with Biomaterials

JPA Pham, MM Coronel - Advanced Healthcare Materials, 2024 - Wiley Online Library
For patients suffering from organ failure due to injury or autoimmune disease, allogeneic
organ transplantation with chronic immunosuppression is considered the gold standard in …

Harnessing Biomaterials to Study and Direct Antigen-Specific Immunotherapy

C Edwards, ST Carey, CM Jewell - ACS Applied Bio Materials, 2023 - ACS Publications
Immunotherapies are an evolving treatment paradigm for addressing cancer, autoimmunity,
and infection. While exciting, most of the existing therapies are limited by their specificity─ …

Combinatorial drug delivery approaches for immunomodulation

JM Stewart, BG Keselowsky - Advanced drug delivery reviews, 2017 - Elsevier
Immunotherapy has been widely explored for applications to both augment and suppress
intrinsic host immunity. Clinical achievements have seen a number of immunotherapeutic …

Engineering antigen-presenting cells for immunotherapy of autoimmunity

CT Smith, Z Wang, JS Lewis - Advanced Drug Delivery Reviews, 2024 - Elsevier
Autoimmune diseases are burdensome conditions that affect a significant fraction of the
global population. The hallmark of autoimmune disease is a host's immune system being …

Biomaterials as local niches for immunomodulation

K Adu-Berchie, DJ Mooney - Accounts of chemical research, 2020 - ACS Publications
Conspectus A major function of the immune system is to detect threat from foreign invaders,
tissue damage, or cancer and to mount a counter response that resolves the threat, restores …

[HTML][HTML] Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond

S Abbaszadeh, V Nosrati-Siahmazgi, K Musaie… - Advanced Drug Delivery …, 2023 - Elsevier
Novel transplantation techniques are currently under development to preserve the function
of impaired tissues or organs. While current technologies can enhance the survival of …