[HTML][HTML] Immune actions on the peripheral nervous system in pain

JA Liu, J Yu, CW Cheung - International journal of molecular sciences, 2021 - mdpi.com
Pain can be induced by tissue injuries, diseases and infections. The interactions between
the peripheral nervous system (PNS) and immune system are primary actions in pain …

Stress/cell death pathways, neuroinflammation, and neuropathic pain

L Li, T Li, X Qu, G Sun, Q Fu, G Han - Immunological reviews, 2024 - Wiley Online Library
Neuropathic pain is a common and debilitating modality of chronic pain induced by a lesion
or disease of the somatosensory nervous system. Albeit the elucidation of numerous …

Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases

H Wang, H Sun, K Della Penna, RJ Benz, J Xu… - Neuroscience, 2002 - Elsevier
Neuropathic pain is induced by injury or disease of the nervous system. Studies aimed at
understanding the molecular pathophysiology of neuropathic pain have so far focused on a …

[HTML][HTML] Mechanistic differences in neuropathic pain modalities revealed by correlating behavior with global expression profiling

EJ Cobos, CA Nickerson, F Gao, V Chandran… - Cell reports, 2018 - cell.com
Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are
incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a …

[HTML][HTML] Persistent alterations in microglial enhancers in a model of chronic pain

F Denk, M Crow, A Didangelos, DM Lopes… - Cell reports, 2016 - cell.com
Chronic pain is a common and devastating condition that induces well-characterized
changes in neurons and microglia. One major unanswered question is why these changes …

Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats

W Jiang, JD Glaeser, G Kaneda, J Sheyn… - Science Translational …, 2023 - science.org
Low back pain (LBP) is often associated with the degeneration of human intervertebral discs
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …

ISSLS PRIZE IN CLINICAL SCIENCE 2018: longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode …

DM Klyne, MF Barbe, W van den Hoorn… - European Spine …, 2018 - Springer
Study design Prospective longitudinal study. Objective To determine whether systemic
cytokines and C-reactive protein (CRP) during an acute episode of low back pain (LBP) …

[HTML][HTML] Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain

M Simonetti, AM Hagenston, D Vardeh, HE Freitag… - Neuron, 2013 - cell.com
Persistent pain induced by noxious stimuli is characterized by the transition from
normosensitivity to hypersensitivity. Underlying mechanisms are not well understood …

Pain regulation by non-neuronal cells and inflammation

RR Ji, A Chamessian, YQ Zhang - Science, 2016 - science.org
Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis,
nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a …

[HTML][HTML] Transcriptome profiling of long noncoding RNAs and mRNAs in spinal cord of a rat model of paclitaxel-induced peripheral neuropathy identifies potential …

Y Li, C Yin, B Liu, H Nie, J Wang, D Zeng… - Journal of …, 2021 - Springer
Background Paclitaxel is a widely prescribed chemotherapy drug for treating solid tumors.
However, paclitaxel-induced peripheral neuropathy (PIPN) is a common adverse effect …