[HTML][HTML] Monocytes/Macrophages control resolution of transient inflammatory pain
Insights into mechanisms governing resolution of inflammatory pain are of great importance
for many chronic pain–associated diseases. Here we investigate the role of macrophages …
for many chronic pain–associated diseases. Here we investigate the role of macrophages …
[HTML][HTML] Human cells and networks of pain: Transforming pain target identification and therapeutic development
Chronic pain is a disabling disease with limited treatment options. While animal models
have revealed important aspects of pain neurobiology, therapeutic translation of this …
have revealed important aspects of pain neurobiology, therapeutic translation of this …
[HTML][HTML] The innate immune response as a mediator of osteoarthritis pain
In this narrative review, we discuss the emerging role of innate immunity in osteoarthritis
(OA) joint pain. First, we give a brief description of the pain pathway in the context of OA …
(OA) joint pain. First, we give a brief description of the pain pathway in the context of OA …
Transition to chronic pain: opportunities for novel therapeutics
Although chronic pain is one of the most important medical problems facing society, there
has been very limited progress in the development of novel therapies for this condition …
has been very limited progress in the development of novel therapies for this condition …
Evidence for shared pain mechanisms in osteoarthritis, low back pain, and fibromyalgia
R Staud - Current rheumatology reports, 2011 - Springer
Osteoarthritis (OA), low back pain (LBP), and fibromyalgia (FM) are common chronic pain
disorders that occur frequently in the general population. They are a significant cause of …
disorders that occur frequently in the general population. They are a significant cause of …
Emerging targets in neuroinflammation-driven chronic pain
Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …
and have limited success in controlling disease progression. Accumulating evidence …
[HTML][HTML] Chronic pain: structural and functional changes in brain structures and associated negative affective states
Chronic pain is a condition in which pain progresses from an acute to chronic state and
persists beyond the healing process. Chronic pain impairs function and decreases patients' …
persists beyond the healing process. Chronic pain impairs function and decreases patients' …
The biology of pain: through the rheumatology lens
Chronic pain is a major socioeconomic burden globally. The most frequent origin of chronic
pain is musculoskeletal. In inflammatory musculoskeletal diseases such as rheumatoid …
pain is musculoskeletal. In inflammatory musculoskeletal diseases such as rheumatoid …
[HTML][HTML] Central pain mechanisms in rheumatic diseases: future directions
K Phillips, DJ Clauw - Arthritis and rheumatism, 2013 - ncbi.nlm.nih.gov
Pain is a prominent component of many rheumatologic conditions, and is the result of a
complex physiologic interaction of central and peripheral nervous system signaling that …
complex physiologic interaction of central and peripheral nervous system signaling that …
Divergent roles of immune cells and their mediators in pain
R Raoof, HLDM Willemen, N Eijkelkamp - Rheumatology, 2018 - academic.oup.com
Chronic pain is a major debilitating condition that is difficult to treat. Although chronic pain
may appear to be a disorder of the nervous system, crucial roles for immune cells and their …
may appear to be a disorder of the nervous system, crucial roles for immune cells and their …