Background Peripheral nerve injury can have long-term consequences including pain-
related manifestations, such as hypersensitivity to cutaneous stimuli, as well as affective and …

Highlights•Neuroinflammation in limbic structures co-occurs in both chronic pain and opioid
dependence.•Major depressive disorder is associated with neuroinflammation.•Chronic pain …

Chronic pain is a leading cause of disability worldwide and its prevalence is likely to
increase over the next decades. Treatment for chronic pain remains insufficient and …

Chronic pain is a major comorbidity of chronic inflammatory diseases. Here, we report that
the cytokine IL-1β, which is abundantly produced during multiple sclerosis (MS), arthritis …

There is a well-established historical observation that structural joint damage by plain X-ray
correlates poorly with symptomatic disease in osteoarthritis (OA). This is often attributed to …

Activation of microglia in the spinal cord following peripheral nerve injury is critical for the
development of long-lasting pain hypersensitivity. However, it remains unclear whether …

It is now widely accepted that the glial cells of the central nervous system (CNS) are key
players in many processes, especially when they are activated via neuron-glia or glia-glia …

Background and Purpose Neutrophil elastase plays a crucial role in arthritis. Here, its
potential in triggering joint inflammation and pain was assessed, and whether these effects …

Chronic pain is a common symptom in rheumatic diseases, and the patient with pain and no
signs of inflammation poses a challenge to the physician. Notably, all rheumatic diseases …

Pain chronicity involves unpleasant experience in both somatosensory and affective
aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However …