Background The amide derivatives of nonsteroidal anti-inflammatory drugs have been
reported to possess antitumor activity. The present work describes the synthesis of …

A library of novel ibuprofen-appended benzoxazole analogues (7a–l) was synthesized via a
series of nitration, reduction, and condensation–cyclization reactions and screened for their …

In this study, a benzidine-based azomethine derivate 2 with a proposed new mechanism
and its two derivatives 4a-b have been designed, synthesized and characterized by 1H, 13C …

In this study, the aim was computer-aided design of a new anti-cancer drug molecule. For
this purpose, 7-hydroxy-8-(((1-hydroxy-3-phenylpropan-2-yl) imino) methyl)-4 …

This report aims to study the chemical properties of a benzamide derivative, N-methyl-2-[[3-
[©-2-pyridin-2-ylethenyl]-1 H-indazol-6-yl] sulfanyl] benzamide (MPSB), having antitumor …

Cancer is a condition marked by abnormal cell proliferation that has the potential to invade
or indicate other health issues. Human beings are affected by more than 100 different types …

A new ibuprofen derivative,(E)-2-(4-isobutylphenyl)-N′-(4-oxopentan-2-ylidene) propane
hydrazide (IA), was synthesized, along with its metal complexes with Co, Cu, Ni, Gd, and …

This research work is based on the synthesis of bis-Schiff base derivatives of the
commercially available ibuprofen drug in outstanding yields through multistep reactions …

In the current investigation, QSAR studies have been performed on fifty-four analogs of the 2-
phenyl-1H-indole analogs, which have antiproliferative activity against two cancer cells lines …

Background: Targeting of multiple sites is a pharmacologically, pharmacokinetic and
dynamically more acceptable approach for complex diseases such as BC. It is …