GAL4-VP16 is an unusually potent transcriptional activator
I Sadowski, J Ma, S Triezenberg, M Ptashne - Nature, 1988 - nature.com
Recent work has defined a class of transcriptional activators1–5, members of which activate
transcription in yeast, plant, insect and mammalian cells6–9. These proteins contain two …
transcription in yeast, plant, insect and mammalian cells6–9. These proteins contain two …
A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives
M Carey, YS Lin, MR Green, M Ptashne - Nature, 1990 - nature.com
IN prokaryotes and eukaryotes many gene activators work synergistically. For example, two
dimers of λ represser interact to promote binding of these proteins to DNA, a reaction that is …
dimers of λ represser interact to promote binding of these proteins to DNA, a reaction that is …
How different eukaryotic transcriptional activators can cooperate promiscuously
YS Lin, M Carey, M Ptashne, MR Green - Nature, 1990 - nature.com
A STRIKING characteristic of many different eukaryotic transcriptional activators is their
ability to activate gene expression synergistically. Thus, for example, the rat glucocorticoid …
ability to activate gene expression synergistically. Thus, for example, the rat glucocorticoid …
Negative effect of the transcriptional activator GAL4
G Gill, M Ptashne - Nature, 1988 - nature.com
The yeast transcriptional activator GAL4 binds specific sites on DNA to activate transcription
of adjacent genes1–5. The distinct activating regions of GAL4 are rich in acidic residues and …
of adjacent genes1–5. The distinct activating regions of GAL4 are rich in acidic residues and …
Expression of a truncated viral trans-activator selectively impedes lytic infection by its cognate virus
AD Friedman, SJ Triezenberg, SL McKnight - Nature, 1988 - nature.com
A virion protein of herpes simplex virus type 1 (HSV-1) specifically and potently activates
transcription of the viral immediate early genes. Appropriate function of this protein, termed …
transcription of the viral immediate early genes. Appropriate function of this protein, termed …
Yeast activators stimulate plant gene expression
J Ma, E Przibilla, J Hu, L Bogorad, M Ptashne - Nature, 1988 - nature.com
GAL4 is a transcriptional activator found in yeast1, 2. Two distinct functions of the protein are
required for its activity3–5: one directs sequen1ce-specific DNA binding, and another …
required for its activity3–5: one directs sequen1ce-specific DNA binding, and another …
GAL4 activates transcription in Drosophila
JA Fischer, E Giniger, T Maniatis, M Ptashne - Nature, 1988 - nature.com
GAL4 is a yeast regulatory protein that binds to specific sites within a DNA sequence called
UASG (galactose upstream activating sequence) and activates transcription of linked …
UASG (galactose upstream activating sequence) and activates transcription of linked …
A potent GAL4 derivative activates transcription at a distance in vitro
M Carey, J Leatherwood, M Ptashne - Science, 1990 - science.org
Transcription of a typical eukaryotic gene by RNA polymerase II is activated by proteins
bound to sites found near the beginning of the gene as well as to sites, called enhancers …
bound to sites found near the beginning of the gene as well as to sites, called enhancers …
Binding of general transcription factor TFIIB to an acidic activating region
YS Lin, I Ha, E Maldonado, D Reinberg, MR Green - Nature, 1991 - nature.com
A CENTRAL issue in eukaryotic transcriptional regulation is the mechanism by which
promoter-specific transcription factors (activators) stimulate transcription. Two lines of …
promoter-specific transcription factors (activators) stimulate transcription. Two lines of …
Structure of the DNA-binding domain of zinc GAL4
PJ Kraulis, ARC Raine, PL Gadhavi, ED Laue - Nature, 1992 - nature.com
THE yeast transcriptional activator GAL4 binds co-operatively to four related 17-base-pair
sequences within an upstream activating sequence (UASG) to activate transcription of the …
sequences within an upstream activating sequence (UASG) to activate transcription of the …