Recent work has defined a class of transcriptional activators1–5, members of which activate
transcription in yeast, plant, insect and mammalian cells6–9. These proteins contain two …

IN prokaryotes and eukaryotes many gene activators work synergistically. For example, two
dimers of λ represser interact to promote binding of these proteins to DNA, a reaction that is …

A STRIKING characteristic of many different eukaryotic transcriptional activators is their
ability to activate gene expression synergistically. Thus, for example, the rat glucocorticoid …

The yeast transcriptional activator GAL4 binds specific sites on DNA to activate transcription
of adjacent genes1–5. The distinct activating regions of GAL4 are rich in acidic residues and …

A virion protein of herpes simplex virus type 1 (HSV-1) specifically and potently activates
transcription of the viral immediate early genes. Appropriate function of this protein, termed …

GAL4 is a transcriptional activator found in yeast1, 2. Two distinct functions of the protein are
required for its activity3–5: one directs sequen1ce-specific DNA binding, and another …

GAL4 is a yeast regulatory protein that binds to specific sites within a DNA sequence called
UASG (galactose upstream activating sequence) and activates transcription of linked …

Transcription of a typical eukaryotic gene by RNA polymerase II is activated by proteins
bound to sites found near the beginning of the gene as well as to sites, called enhancers …

A CENTRAL issue in eukaryotic transcriptional regulation is the mechanism by which
promoter-specific transcription factors (activators) stimulate transcription. Two lines of …

THE yeast transcriptional activator GAL4 binds co-operatively to four related 17-base-pair
sequences within an upstream activating sequence (UASG) to activate transcription of the …