The epithelium plays an active role in the response to inhaled pathogens in part by
responding to signals from the immune system. Epithelial responses may include changes …

Abstract Interleukin-13 (IL13) is a major player in the development of airway
hyperresponsiveness in several respiratory disorders. Emerging data suggest that an …

The expression and function of the anion exchanger pendrin (SLC26A4) was thought to be
limited mainly to the inner ear, kidney and thyroid. Recent data indicates that pendrin is also …

Excessive production of airway mucus is a cardinal feature of bronchial asthma and chronic
obstructive pulmonary disease (COPD) and contributes to morbidity and mortality in these …

Background: Pendrin, an anion exchanger associated with the inner ear, thyroid and kidney,
plays a significant role in respiratory tissues and diseases, where its expression is increased …

Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport
mechanisms in the airways are not well understood. cAMP stimulates anion efflux through …

Signaling through the interleukin‐4/interleukin‐13 (IL‐4/IL‐13) receptor complex is a crucial
mechanism in the development of bronchial asthma and chronic obstructive pulmonary …

The pH of airway surface liquid (ASL) is a key factor that determines respiratory host
defense; ASL acidification impairs and alkalinization enhances key defense mechanisms …

Pendrin (SLC26A4), a Cl−/anion exchanger, is expressed at high levels in kidney, thyroid,
and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride …

Objective: The aim of this study is to evaluate the role of pendrin in acute lung injury
(ALI)/acute respiratory distress syndrome (ARDS) and to explore whether pendrin …