Studies with the isolated perfused working rat heart were carried out to investigate factors
that may enable the heart to recover after periods of anoxia. It was found that the presence of …

1. The kinetic properties of the soluble and particulate hexokinases from rat heart have been
investigated. 2. For both forms of the enzyme, the Km for glucose was 45μm and the Km for …

During a 15-minute period of myocardial ischemia, glycogen concentration fell. This
decrease was roughly accounted for by increases in hexosemonophosphate and lactic acid …

Isolated rat heart was perfused with Langendorff's retrograde perfusion method, while the
oxygen consumption and the left ventricular pressure were monitored continually. The …

Cyclical changes in energy-related metabolites were observed in glucose-perfused but not
pyruvate-perfused isolated working rat hearts. A chronological study of various phases of the …

An isolated perfused working rat heart preparation was used to assess the effect of alloxan-
induced diabetes on myocardial performance. Ventricular performance was assessed under …

We postulated that glycogen is a significant energy substrate compared with fatty acids and
glucose in response to adrenergic stimulation of working rat hearts. Oxidation rates were …

1. Incubation of hepatocytes from fed or starved rats with increasing glucose concentrations
caused a stimulation of lactate production, which was further increased under anaerobic …

The effects of hypercapnia have been studied in rat hearts perfused with glucose and
insulin. At pH 6.7 to 6.8, two different responses were observed. One was characterized by a …

Alterations in blood flow distribution in streptozotocin-induced diabetes in the rat were
examined. Blood flow between tissues was estimated by the distribution of radiolabeled …