Leptin, as a link between fat mass and the brain, has been reported to be associated with
gender. The gender differences in leptin levels between Alzheimer's disease (AD) and …

Background: Low plasma leptin levels can be a risk factor for Alzheimer's disease (AD) but
the relation of leptin with disease progression in clinical AD is unknown. Objective: The aim …

Background: Metabolic dysfunction links to cognitive deficits in Alzheimer's disease (AD).
Leptin is an anti-obesity hormone that modulates energy homeostasis and memory function …

Introduction: Leptin receptors have been identified in many peripheral tissues as well as the
CNS including the hippocampus, which is particularly vulnerable in Alzheimer's disease …

Methods: Thirty patients meeting the clinical diagnostic criteria for AD, and twenty-five
healthy controls were enrolled into the study. At baseline, all patients underwent standing …

Background: There is growing interest in the pathophysiological processes of preclinical
Alzheimer's disease (AD), including the potential role of leptin. Human studies have shown …

Background: US studies suggest that leptin, a fat-derived hormone, may be protective
against the development of dementia. Objective: To investigate the complex relationship …

Context The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the
hippocampus, promotes β-amyloid clearance, and improves memory function in animal …

Analysis of data derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI)
program showed plasma leptin levels in individuals with Mild Cognitive Impairment (MCI) or …

Background. The association between obesity and dementia has been inconsistent,
possibly due to changes in body composition often seen in old age. Leptin may be …