Endogenous adenosine is a widely distributed upstream regulator of a broad spectrum of
neurotransmitters, receptors, and signaling pathways that converge to contribute to the …

The identification and characterization of adenosine receptors and the development of
potent, receptor subtype-selective agonist and antagonists has been an active area of …

Ever since the discovery of the hypotensive and bradycardiac effects of adenosine,
adenosine receptors continue to represent promising drug targets. First, this is due to the fact …

By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular energy …

Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …

Adenosine is a metabolite generated and released from cells, particularly under injury or
stress. It elicits protective or damaging responses via signaling through the adenosine …

There are four adenosine receptors, A1, A2A, A2B and A3, together forming a defined
subgroup of G protein coupled receptors. They are well conserved and widely expressed …

A3 Adenosine receptors (ARs) exhibit large species differences. Potent, selective agonists
for rat (eg Cl-IB-MECA, 5) and human A3 ARs (eg PENECA, 17, and analogs) have been …

The adenosine A 1 receptor (A 1-AR) is a G-protein-coupled receptor that plays a vital role in
cardiac, renal, and neuronal processes but remains poorly targeted by current drugs. We …

Abstract The A 1, A 2A, A 2B and A 3 G-protein-coupled cell surface adenosine receptors
(ARs) are found to be upregulated in various tumor cells. Activation of the receptors by …