Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated …
A Bresciani, A Missineo, M Gallo, M Cerretani… - Archives of biochemistry …, 2017 - Elsevier
Mechanisms that activate innate antioxidant responses, as a way to mitigate oxidative stress
at the site of action, hold much therapeutic potential in diseases, such as Parkinson's …
at the site of action, hold much therapeutic potential in diseases, such as Parkinson's …
NRF2: new mechanistic insights and therapeutic perspectives
JW Kupiec-Weglinski - Antioxidants & Redox Signaling, 2024 - liebertpub.com
Targeted modulation of a dynamic interplay between transcription factor nuclear factor
erythroid 2-related factor 2 (NRF2) and its negative regulator, Kelch-like ECH-associated …
erythroid 2-related factor 2 (NRF2) and its negative regulator, Kelch-like ECH-associated …
Modulation of NRF2: biological dualism in cancer, targets and possible therapeutic applications
M Gallorini, S Carradori, E Panieri, M Sova… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …
NRF2-targeted therapeutics: New targets and modes of NRF2 regulation
Pharmacological activation of the transcription factor nuclear factor-erythroid derived 2-like 2
(NRF2), the key regulator of the cellular antioxidant response, has been recognized as a …
(NRF2), the key regulator of the cellular antioxidant response, has been recognized as a …
[HTML][HTML] Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the master regulator of the antioxidant
response, and its function is tightly regulated at the transcriptional, translational, and post …
response, and its function is tightly regulated at the transcriptional, translational, and post …
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
E Crisman, P Duarte, E Dauden… - Medicinal research …, 2023 - Wiley Online Library
The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the
master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective …
master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective …
[HTML][HTML] Nrf2 in host defense: over the rainbow
HY Cho, MK Kwak, J Pi - Oxidative medicine and cellular longevity, 2013 - ncbi.nlm.nih.gov
Nuclear factor (erythroid-derived 2)-like 2 or NF-E2-related factor 2 (NRF2 or Nrf2 for
rodents), was discovered about two decades ago and has been known as a key …
rodents), was discovered about two decades ago and has been known as a key …
Replacement of a naphthalene scaffold in Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor (erythroid-derived 2)-like 2 (NRF2) inhibitors
BG Richardson, AD Jain, HR Potteti… - Journal of medicinal …, 2018 - ACS Publications
Activators of nuclear factor-erythroid 2-related factor 2 (NRF2) could lead to promising
therapeutics for prevention and treatment of oxidative stress and inflammatory disorders …
therapeutics for prevention and treatment of oxidative stress and inflammatory disorders …
Recent progress in the development of small molecule Nrf2 activators: a patent review (2017-present)
H Zhou, Y Wang, Q You, Z Jiang - Expert Opinion on Therapeutic …, 2020 - Taylor & Francis
ABSTRACT Introduction: The transcription factor Nrf2 (nuclear factor erythroid 2-related
factor 2) is the first line of defense against a plethora of environmental or endogenous …
factor 2) is the first line of defense against a plethora of environmental or endogenous …
Characterization of the potent, selective Nrf2 activator, 3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2h-chromen-2-one, in cellular and in vivo models of pulmonary …
JG Yonchuk, JP Foley, BJ Bolognese, G Logan… - … of Pharmacology and …, 2017 - ASPET
Nuclear factor (erythroid-derived 2)–like 2 (Nrf2) is a key regulator of oxidative stress and
cellular repair and can be activated through inhibition of its cytoplasmic repressor, Kelch-like …
cellular repair and can be activated through inhibition of its cytoplasmic repressor, Kelch-like …
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