Keratin defects trigger the itch-inducing cytokine thymic stromal lymphopoietin through amphiregulin–epidermal growth factor receptor signaling

A Scheffschick, D Kiritsi, TM Magin - Journal of Allergy and Clinical …, 2019 - jacionline.org
REFERENCES 1. Georas SN, Rezaee F. Epithelial barrier function: at the front line of
asthma immunology and allergic airway inflammation. J Allergy Clin Immunol 2014; 134 …

Keratin-dependent thymic stromal lymphopoietin expression suggests a link between skin blistering and atopic disease

V Kumar, M Behr, D Kiritsi, A Scheffschick… - Journal of Allergy and …, 2016 - jacionline.org
To the Editor: Atopic dermatitis (AD) is a pruritic and inflammatory skin disorder
characterized by barrier disruption. The cytokine thymic stromal lymphopoietin (TSLP), a …

Thymic stromal lymphopoietin, skin barrier dysfunction, and the atopic march

SF Ziegler - Annals of Allergy, Asthma & Immunology, 2021 - Elsevier
Objective Atopic dermatitis often precedes the development of other atopic diseases, and
the atopic march describes this temporal relationship in the natural history of these diseases …

Thymic stromal lymphopoietin downregulates filaggrin expression by signal transducer and activator of transcription 3 (STAT3) and extracellular signal-regulated …

JH Kim, HC Bae, NY Ko, SH Lee, SH Jeong… - Journal of Allergy and …, 2015 - jacionline.org
The present study shows that human keratinocytes and skin express the receptor for TSLP.
We investigated whether TSLP is involved in filaggrin expression in primary human …

Counterregulation between thymic stromal lymphopoietin–and IL-23–driven immune axes shapes skin inflammation in mice with epidermal barrier defects

J Li, JM Leyva-Castillo, P Hener, A Eisenmann… - Journal of Allergy and …, 2016 - Elsevier
Background Epidermal barrier dysfunction has been recognized as a critical factor in the
initiation and exacerbation of skin inflammation, particularly in patients with atopic dermatitis …

[HTML][HTML] Increased affected skin gene expression and serum levels of thymic stromal lymphopoietin in atopic dermatitis

KD Alysandratos, A Angelidou, M Vasiadi… - Annals of allergy …, 2010 - ncbi.nlm.nih.gov
Atopic dermatitis (AD) is a chronic highly pruritic inflammatory skin disease, which has
increased considerably in industrialized countries. 1 AD is characterized by allergic …

Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis

J Landheer, B Giovannone, JD Mattson… - Journal of allergy and …, 2013 - jacionline.org
To the Editor: Aeroallergens, including house dust mite (HDM) allergens, have been
implicated in the pathogenesis of atopic dermatitis (AD). Epicutaneous application of HDM …

[HTML][HTML] Thymic stromal lymphopoietin expression in allergic pulmonary inflammation is Pin1-dependent

S Esnault, LA Rosenthal, ZJ Shen… - The Journal of allergy …, 2008 - ncbi.nlm.nih.gov
Thymic stromal lymphopoietin (TSLP) may be a novel link between the activation of
fibroblasts, epithelial cells, and keratinocytes after exposure to environmental stimuli and the …

Resistance to apoptosis underpins the corticosteroid insensitivity of group 2 innate lymphoid cells

J Luo, Y Wu, R Shrimanker, S Go, Y Ye… - Journal of Allergy and …, 2019 - jacionline.org
Resistance to apoptosis underpins the corticosteroid insensitivity of group 2 innate lymphoid
cells blocking antibody reduced secreted TSLP levels by approximately 35% in KtyI 2/2 cells …

The role of thymic stromal lymphopoietin in the immunopathogenesis of atopic dermatitis

SP Jariwala, E Abrams, A Benson… - Clinical & …, 2011 - Wiley Online Library
Atopic dermatitis (AD), a skin disease characterized by pruritus and chronic inflammation,
results from a complex interplay between environmental and genetic factors. Thymic stromal …