Distinct microbial and immune niches of the human colon
Gastrointestinal microbiota and immune cells interact closely and display regional
specificity; however, little is known about how these communities differ with location. Here …
specificity; however, little is known about how these communities differ with location. Here …
The microbiota in adaptive immune homeostasis and disease
K Honda, DR Littman - Nature, 2016 - nature.com
In the mucosa, the immune system's T cells and B cells have position-specific phenotypes
and functions that are influenced by the microbiota. These cells play pivotal parts in the …
and functions that are influenced by the microbiota. These cells play pivotal parts in the …
The gut microbiota is associated with immune cell dynamics in humans
The gut microbiota influences development,–and homeostasis,,–of the mammalian immune
system, and is associated with human inflammatory and immune diseases, as well as …
system, and is associated with human inflammatory and immune diseases, as well as …
Regulation of inflammation by microbiota interactions with the host
The study of the intestinal microbiota has begun to shift from cataloging individual members
of the commensal community to understanding their contributions to the physiology of the …
of the commensal community to understanding their contributions to the physiology of the …
Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells
The intestinal microbiota has a critical role in immune system and metabolic homeostasis,
but it must be tolerated by the host to avoid inflammatory responses that can damage the …
but it must be tolerated by the host to avoid inflammatory responses that can damage the …
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut
Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell
responses, but the mechanisms controlling these distinct outcomes remain poorly …
responses, but the mechanisms controlling these distinct outcomes remain poorly …
A dynamic atlas of immunocyte migration from the gut
Dysbiosis in the gut microbiota affects several systemic diseases, possibly by driving the
migration of perturbed intestinal immunocytes to extraintestinal tissues. Combining Kaede …
migration of perturbed intestinal immunocytes to extraintestinal tissues. Combining Kaede …
The microbiome and innate immunity
The intestinal microbiome is a signalling hub that integrates environmental inputs, such as
diet, with genetic and immune signals to affect the host's metabolism, immunity and …
diet, with genetic and immune signals to affect the host's metabolism, immunity and …
The role of the immune system in governing host-microbe interactions in the intestine
The mammalian intestinal tract harbors a diverse community of trillions of microorganisms,
which have co-evolved with the host immune system for millions of years. Many of these …
which have co-evolved with the host immune system for millions of years. Many of these …
Circulating and tissue-resident CD4+ T cells with reactivity to intestinal microbiota are abundant in healthy individuals and function is altered during inflammation
Background & Aims Interactions between commensal microbes and the immune system are
tightly regulated and maintain intestinal homeostasis, but little is known about these …
tightly regulated and maintain intestinal homeostasis, but little is known about these …